Aggregate Data Modelling R package admixr2 version 0.1.0 Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>. Software Depends: R (>= 4.1.0) Imports: checkmate, digest, nlmixr2est, nloptr, qs2, randtoolbox, Rcpp, rxode2 LinkingTo: Rcpp, RcppEigen Suggests: expm, furrr, future, ggplot2, knitr, mnormt, nlmixr2, patchwork, rmarkdown, testthat (>= 3.0.0) H. van de Beek <h.van.de.beek@lacdr.leidenuniv.nl> Comprehensive R Archive Network (CRAN) H. van de Beek [aut, cre], P.A.J. Välitalo [aut], L.B. Zwep [aut], J.G.C. van Hasselt [aut] GPL (>= 3) 2026-06-02 application/tgz https://CRAN.R-project.org/package=admixr2 doi:10.32614/CRAN.package.admixr2