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# tcplfit2: A Concentration-Response Modeling Utility

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## Welcome to the GitHub repository for the tcplfit2 package.

<a href="https://CRAN.R-project.org/package=tcplfit2"><img src="vignettes/img/tcplfit2_hex.png" width="200" align="right" /></a>

The tcplfit2 R package performs basic concentration-response curve
fitting. The original tcplFit() function in the [ToxCast Data Analysis
Pipeline (tcpl) R
package](https://github.com/USEPA/CompTox-ToxCast-tcpl) performed basic
concentration-response curvefitting to 3 models. With tcplfit2, the core
tcpl concentration-response functionality has been expanded to process
diverse high-throughput screen (HTS) data generated at the US
Environmental Protection Agency, including targeted ToxCast,
high-throughput transcriptomics (HTTr) and high-throughput phenotypic
profiling (HTPP). tcplfit2 can be used independently to support analysis
for diverse chemical screening efforts.

If you are interested in contributing or want to report a bug, please
submit a issue or start a discussion.

To install the current development version, run the following command:

    devtools::install_github("USEPA/CompTox-ToxCast-tcplfit2")

### Disclaimer

The United States Environmental Protection Agency (EPA) GitHub project
code is provided on an “as is” basis and the user assumes responsibility
for its use. EPA has relinquished control of the information and no
longer has responsibility to protect the integrity, confidentiality, or
availability of the information. Any reference to specific commercial
products, processes, or services by service mark, trademark,
manufacturer, or otherwise, does not constitute or imply their
endorsement, recommendation or favoring by EPA. The EPA seal and logo
shall not be used in any manner to imply endorsement of any commercial
product or activity by EPA or the United States Government.
