Type: Package
Package: splinetrials
Title: Facilitate Clinical Trials Analysis Using Natural Cubic Splines
Version: 0.1.1
Authors@R: c(
    person("Nik", "Krieger", , "nikkrieger@gmail.com", role = c("aut", "cre")),
    person("Daniel", "Sabanes Bove", , "daniel@rconis.com", role = "ctb"),
    person("Eli Lilly and Company", role = "cph")
  )
Description: Create mixed models with repeated measures using natural
    cubic splines applied to an observed continuous time variable, as
    described by Donohue et al. (2023) <doi:10.1002/pst.2285>. Iterate
    through multiple covariance structure types until one converges.
    Categorize observed time according to scheduled visits. Perform
    subgroup analyses.
License: Apache License (>= 2)
URL: https://github.com/NikKrieger/splinetrials,
        https://nikkrieger.github.io/splinetrials/
BugReports: https://github.com/NikKrieger/splinetrials/issues
Imports: car, cli, dplyr, emmeans, mmrm (>= 0.3.16), rlang, splines
Suggests: ggplot2, survival, testthat (>= 3.0.0)
Config/testthat/edition: 3
Encoding: UTF-8
RoxygenNote: 7.3.3
NeedsCompilation: no
Packaged: 2026-01-19 13:00:00 UTC; nik
Author: Nik Krieger [aut, cre],
  Daniel Sabanes Bove [ctb],
  Eli Lilly and Company [cph]
Maintainer: Nik Krieger <nikkrieger@gmail.com>
Repository: CRAN
Date/Publication: 2026-01-19 13:20:09 UTC
Built: R 4.6.0; ; 2026-04-25 14:06:08 UTC; unix
