analyzeSP23Design       Analyses the results of running a design. If a
                        trial history, such as the result of the
                        function 'executeSP23Design' or a history of
                        the actual conduct of a single trial is
                        provided, it returns the analysis results.
computeDGivenXi         Given the estimates of the pi and theta,
                        compute d.
computeGammaSubT        Compute the estimate of the variance of the
                        generalized likelihood ratio statistic at time
                        t
computeResponseSummary
                        Given interim data, compute the response
                        end-point summary
executeSP23Design       Given a design object, interim data and the
                        current calendar time, conduct the interim
                        analysis for the time
exploreSP23Design       Explore a specified design by simulation
generateClinicalTrialData
                        A function to generate some clinical trial data
                        according the joint model of response and
                        survival for simulations
generateInterimData     Generate interim data for a clinical trial from
                        a data set.
generateSP23Design      Generate a seamless Phase II-III design object
                        given some the true parameters and clinical
                        trial parameters
hessian                 A utility function to compute the hessian of
                        the generalized (conditional) partial
                        likelihood ratio statistic
loglik1                 Compute the response log-likelihood
loglik1GivenDelta       Computes the constrained response
                        log-likelihood (on the alternative)
loglik2                 Computes the survival log-likelihood
loglik2.repar0          Computes the constrained survival
                        log-likelihood
mHP.b                   Compute the modified Haybittle-Peto boundary
mHP.c                   Compute the modified Haybittle-Peto boundary
                        for the final look
performInterimLook      Perform an interim look in a seamless Phase
                        II-III clinical trial
resetSP23Design         Reset the design object so that counts and
                        results are zeroed out
solveForCGivenABD       A convenience function to reduce dimension by
                        solving for one variable c in terms of others
                        a, b, d
sp23design-package      sp23design: A package for the design,
                        exploration and execution of seamless Phase
                        II-II clinical trials
