R: Design and Simulation of Seamless Phase II-III Clinical Trials

# Design and Simulation of Seamless Phase II-III Clinical Trials

## Documentation for package ‘sp23design’ version 0.9-1

- DESCRIPTION file
- User guides, package vignettes and other documentation

## Help Pages

sp23design-package | sp23design: A package for the design, exploration and execution of seamless Phase II-II clinical trials
analyzeSP23Design | Analyses the results of running a design. If a trial history, such as the result of the function 'executeSP23Design' or a history of the actual conduct of a single trial is provided, it returns the analysis results.
computeDGivenXi | Given the estimates of the pi and theta, compute d.
computeGammaSubT | Compute the estimate of the variance of the generalized likelihood ratio statistic at time t
computeResponseSummary | Given interim data, compute the response end-point summary
executeSP23Design | Given a design object, interim data and the current calendar time, conduct the interim analysis for the time
exploreSP23Design | Explore a specified design by simulation
generateClinicalTrialData | A function to generate some clinical trial data according the joint model of response and survival for simulations
generateInterimData | Generate interim data for a clinical trial from a data set.
generateSP23Design | Generate a seamless Phase II-III design object given some the true parameters and clinical trial parameters
hessian | A utility function to compute the hessian of the generalized (conditional) partial likelihood ratio statistic
loglik1 | Compute the response log-likelihood
loglik1GivenDelta | Computes the constrained response log-likelihood (on the alternative)
loglik2 | Computes the survival log-likelihood
loglik2.repar0 | Computes the constrained survival log-likelihood
mHP.b | Compute the modified Haybittle-Peto boundary
mHP.c | Compute the modified Haybittle-Peto boundary for the final look
performInterimLook | Perform an interim look in a seamless Phase II-III clinical trial
resetSP23Design | Reset the design object so that counts and results are zeroed out
solveForCGivenABD | A convenience function to reduce dimension by solving for one variable c in terms of others a, b, d
sp23design | sp23design: A package for the design, exploration and execution of seamless Phase II-II clinical trials