Package: simaerep
Title: Detect Clinical Trial Sites Over- or Under-Reporting Clinical
        Events
Version: 1.0.0
Authors@R: c(
    person(given = "Bjoern",
           family = "Koneswarakantha",
           role = c("aut", "cre", "cph"),
           email = "bjoern.koneswarakantha@roche.com",
           comment = c(ORCID = "0000-0003-4585-7799")),
    person("F. Hoffmann-La Roche Ltd",
           role = c("cph"))
  )
Description: Monitoring reporting rates of subject-level clinical events (e.g.
  adverse events, protocol deviations) reported by clinical trial sites is an
  important aspect of risk-based quality monitoring strategy. Sites that are 
  under-reporting or over-reporting events can be detected using bootstrap
  simulations during which patients are redistributed between sites. Site-specific
  distributions of event reporting rates  are generated that are used to assign
  probabilities to the observed reporting rates.
  (Koneswarakantha 2024 <doi:10.1007/s43441-024-00631-8>).
URL: https://openpharma.github.io/simaerep/,
        https://github.com/openpharma/simaerep/
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 4.0), ggplot2
Imports: dplyr (>= 1.1.0), tidyr (>= 1.1.0), magrittr, purrr, rlang,
        stringr, forcats, cowplot, RColorBrewer, furrr (>= 0.2.1),
        progressr, knitr, tibble, dbplyr, glue
Suggests: testthat, devtools, pkgdown, spelling, haven, vdiffr, lintr,
        DBI, duckdb, ggExtra
RoxygenNote: 7.3.2
Language: en-US
Config/testthat/edition: 3
NeedsCompilation: no
Packaged: 2025-10-28 11:22:11 UTC; koneswab
Author: Bjoern Koneswarakantha [aut, cre, cph] (ORCID:
    <https://orcid.org/0000-0003-4585-7799>),
  F. Hoffmann-La Roche Ltd [cph]
Maintainer: Bjoern Koneswarakantha <bjoern.koneswarakantha@roche.com>
Repository: CRAN
Date/Publication: 2025-10-28 11:40:02 UTC
Built: R 4.6.0; ; 2026-04-26 21:38:35 UTC; unix
