R: Simulation and Group Sequential Monitoring of Randomized Two-Stage Treatment Efficacy Trials with Time-to-Event Endpoints

# Simulation and Group Sequential Monitoring of Randomized Two-Stage Treatment Efficacy Trials with Time-to-Event Endpoints

## Documentation for package ‘seqDesign’ version 1.2

- DESCRIPTION file
- User guides, package vignettes and other documentation
- Package README

## Help Pages

censTrial | Generation of Pre-Unblinded Follow-Up Data-Sets by Applying the Monitoring Outcomes
getBlockSize | Determine block size for use in blocked randomization
monitorTrial | Group Sequential Monitoring of Simulated Efficacy Trials for the Event of Potential Harm, Non-Efficacy, and High Efficacy
rankTrial | Ranking and Selection, and Head-to-Head Comparison of Individual and Pooled Treatment Arms
simTrial | Simulation of Multi-Arm Randomized Phase IIb/III Efficacy Trials with Time-to-Event Endpoints
VEpowerPP | Unconditional Power to Detect Positive Treatment Efficacy in a Per-Protocol Cohort