.twoBitCode             2-bit code helper
aco.operator            ACO operator for model selection
acoControl              Create control parameters for the ACO algorithm
add_covariate           Add a covariate effect to a parameter model
add_variability         Add inter-individual variability to a parameter
applyParamDeps          Apply parameter dependency rules
auto_param_table        Automatically generate a parameter table with
                        initial estimates
base_model              Create a base model code for single-start model
                        search algorithms
build_odeline           Build ODE model lines for pharmacokinetic
                        modeling
create.pop              Create an initial GA population
createAnts              Create ant population for ACO
decodeBinary            Decode binary encoding to categorical encoding
detect_move             Detect the primary move between two model codes
encodeBinary            Encode categorical encoding to binary encoding
fitness                 Evaluate fitness of a population
                        pharmacokinetic model
ga.crossover            Crossover operator (one- or two-point) for
                        binary chromosomes
ga.mutation             Mutation operator for binary genetic algorithms
ga.operator             Genetic algorithm operator for model selection
ga.sel.tournament       Tournament selection
gaControl               Control parameters for genetic algorithm
generate_neighbors_df   Generate neighbor models
get.mod.lst             Summarize parameter estimates and run
                        information from an nlmixr2 fit
initNodeList            Initialize node list for ACO search space
initialize_param        Initialize model parameters from parameter
                        table
initialize_param_table
                        Generate initial parameter table for
                        pharmacometric model estimation
is_move_tabu            Check if a move is tabu
mod.run                 Run population pharmacokinetic model with
                        pre-defined search space
omega_block             Generate omega block Code for nlmixr2 model
p.calculation           Calculate selection probabilities for each node
param.bounds            Define Parameter Bounds for PK Models
parseName               Parse model coding vector to model name
parseParams             Parse string vector to model parameters
penaltyControl          Configure penalty settings for model evaluation
perturb_2bit            Apply 2-bit perturbation to escape local
                        optimum
phi.calculate           Update pheromone levels for each decision node
ppkmodGen               Generate a Pharmacokinetic (PK) Model for
                        nlmixr2
print.acoOperatorResult
                        Print method for ACO operator results
print.gaOperatorResult
                        Print method for gaOperatorResult objects
print.sfOperatorResult
                        Print method for sfOperatorResult objects
print.tabuOperatorResult
                        Print method for tabu operator results
rank_new                Ranking with significance difference threshold
run_model_in_subprocess
                        Run an nlmixr2 model in an isolated subprocess
runlocal                Perform 1-bit local search
sf.operator             Stepwise model building operator for model
                        selection
spaceConfig             Get search space configuration
step_compartments       Screen number of compartments
step_correlation        Evaluate inclusion of ETA correlation structure
step_elimination        Screen elimination type (linear vs
                        Michaelis-Menten)
step_iiv_f              Forward selection of IIV on structural
                        parameters
step_iiv_ka             Evaluate inter-individual variability on Ka
step_iiv_km             Evaluate inter-individual variability on Km
step_rv                 Evaluate residual error model structure
tabu.operator           Tabu search operator for model selection
tabuControl             Control Parameters for Tabu Search
validStringbinary       Validate and correct model string for GA
validStringcat          Validate and correct model string for ACO/TS
