format-version: 1.2
data-version: releases/2025-02-06
subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3."
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_obsoletion_candidate "Terms planned for obsoletion"
subsetdef: goslim_agr "AGR slim"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_chembl "ChEMBL protein targets summary"
subsetdef: goslim_drosophila "Drosophila GO slim"
subsetdef: goslim_euk_cellular_processes_ribbon "GO ribbon for eukaroytic cellular processes"
subsetdef: goslim_flybase_ribbon "Insecta GO ribbon slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_mouse "Mouse GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_plant_ribbon "Plant GO ribbon"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_prokaryote "GO subset for prokaryotes"
subsetdef: goslim_prokaryote_ribbon "Prokaryote GO ribbon slim"
subsetdef: goslim_synapse "synapse GO slim"
subsetdef: goslim_virus "GO subset for viruses"
subsetdef: goslim_yeast "Yeast GO slim"
synonymtypedef: syngo_official_label "label approved by the SynGO project"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
ontology: go

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
alt_id: GO:0000498
alt_id: GO:0044822
def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "base pairing with RNA" NARROW []
synonym: "poly(A) RNA binding" RELATED []
synonym: "poly(A)-RNA binding" RELATED []
synonym: "poly-A RNA binding" RELATED []
xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0001948
alt_id: GO:0045308
def: "Binding to a protein." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "glycoprotein binding" NARROW []
synonym: "protein amino acid binding" EXACT []
xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH"
is_a: GO:0005488 ! binding


[Term]
id: GO:0046872
name: metal ion binding
namespace: molecular_function
def: "Binding to a metal ion." [GOC:ai]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "heavy metal binding" NARROW []
synonym: "metal binding" EXACT []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
xref: NIF_Subcellular:sao101633890
xref: Wikipedia:Cytosol
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0002929
name: MECO complex
namespace: cellular_component
def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642]
synonym: "meta-coactivator complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: GO:0002944
name: cyclin K-CDK12 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk12 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0002945
name: cyclin K-CDK13 complex
namespace: cellular_component
def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]
synonym: "CycK/Cdk13 complex" RELATED []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0002946
name: tRNA C5-cytosine methylation
namespace: biological_process
def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:155581073X]
synonym: "tRNA 5-methylcytosine biosynthesis" RELATED []
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002949
name: tRNA threonylcarbamoyladenosine modification
namespace: biological_process
alt_id: GO:0070526
def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]
synonym: "t6A biosynthesis" EXACT [PMID:19287007]
synonym: "t6A biosynthetic process" EXACT [PMID:19287007]
synonym: "t6A tRNA modification" EXACT []
synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT []
synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process
