R: Group Sequential Design with Non-Constant Effect

# Group Sequential Design with Non-Constant Effect

## Documentation for package ‘gsDesign2’ version 1.1.8

- DESCRIPTION file
- User guides, package vignettes and other documentation
- Package NEWS
- Package README

## Help Pages

ahr | Average hazard ratio under non-proportional hazards
ahr_blinded | Blinded estimation of average hazard ratio
as_gt | Convert summary table of a fixed or group sequential design object to a gt object
as_gt.fixed_design_summary | Convert summary table of a fixed or group sequential design object to a gt object
as_gt.gs_design_summary | Convert summary table of a fixed or group sequential design object to a gt object
as_rtf | Write summary table of a fixed or group sequential design object to an RTF file
as_rtf.fixed_design_summary | Write summary table of a fixed or group sequential design object to an RTF file
as_rtf.gs_design_summary | Write summary table of a fixed or group sequential design object to an RTF file
define_enroll_rate | Define enrollment rate
define_fail_rate | Define failure rate
expected_accrual | Piecewise constant expected accrual
expected_event | Expected events observed under piecewise exponential model
expected_time | Predict time at which a targeted event count is achieved
fixed_design_ahr | Fixed design under non-proportional hazards
fixed_design_fh | Fixed design under non-proportional hazards
fixed_design_lf | Fixed design under non-proportional hazards
fixed_design_maxcombo | Fixed design under non-proportional hazards
fixed_design_mb | Fixed design under non-proportional hazards
fixed_design_milestone | Fixed design under non-proportional hazards
fixed_design_rd | Fixed design under non-proportional hazards
fixed_design_rmst | Fixed design under non-proportional hazards
gs_b | Default boundary generation
gs_bound_summary | Bound summary table
gs_cp_npe | Conditional power computation with non-constant effect size
gs_create_arm | Create npsurvSS arm object
gs_design_ahr | Calculate sample size and bounds given targeted power and Type I error in group sequential design using average hazard ratio under non-proportional hazards
gs_design_combo | Group sequential design using MaxCombo test under non-proportional hazards
gs_design_npe | Group sequential design computation with non-constant effect and information.
gs_design_rd | Group sequential design of binary outcome measuring in risk difference
gs_design_wlr | Group sequential design using weighted log-rank test under non-proportional hazards
gs_info_ahr | Information and effect size based on AHR approximation
gs_info_combo | Information and effect size for MaxCombo test
gs_info_rd | Information and effect size under risk difference
gs_info_wlr | Information and effect size for weighted log-rank test
gs_power_ahr | Group sequential design power using average hazard ratio under non-proportional hazards
gs_power_combo | Group sequential design power using MaxCombo test under non-proportional hazards
gs_power_design_npe | Group sequential design computation with non-constant effect and information.
gs_power_npe | Group sequential design computation with non-constant effect and information.
gs_power_rd | Group sequential design power of binary outcome measuring in risk difference
gs_power_wlr | Group sequential design power using weighted log rank test under non-proportional hazards
gs_spending_bound | Derive spending bound for group sequential boundary
gs_spending_combo | Derive spending bound for MaxCombo group sequential boundary
gs_update_ahr | Group sequential design using average hazard ratio under non-proportional hazards
ppwe | Piecewise exponential cumulative distribution function
pw_info | Average hazard ratio under non-proportional hazards
s2pwe | Approximate survival distribution with piecewise exponential distribution
summary.fixed_design | Summary for fixed design or group sequential design objects
summary.gs_design | Summary for fixed design or group sequential design objects
text_summary | Generates a textual summary of a group sequential design using the AHR method.
to_integer | Round sample size and events
to_integer.fixed_design | Round sample size and events
to_integer.gs_design | Round sample size and events
wlr_weight | Weight functions for weighted log-rank test
wlr_weight_1 | Weight functions for weighted log-rank test
wlr_weight_fh | Weight functions for weighted log-rank test
wlr_weight_mb | Weight functions for weighted log-rank test
wlr_weight_n | Weight functions for weighted log-rank test