Package: grantham
Type: Package
Title: Calculate the Grantham Distance
Version: 0.1.4
Authors@R: c(
    person(given = "Ramiro", family = "Magno",
      email = "rmagno@pattern.institute",
      role = c("aut", "cre"),
      comment = c(ORCID = "0000-0001-5226-3441")),
    person(given = "Isabel", family = "Duarte",
      email = "iduarte@pattern.institute",
      role = "aut",
      comment = c(ORCID = "0000-0003-0060-2936")),
    person(given = "Ana-Teresa", family = "Maia",
      email = "maia.anateresa@gmail.com",
      role = "aut", 
      comment = c(ORCID = "0000-0002-0454-9207")),
    person("University of Algarve", role = "fnd"),
    person("CINTESIS", role = "fnd"),
    person("Pattern Institute", role = c("cph", "fnd"), comment = c(ROR = "04jrgd746"))
    )
Description: A minimal set of routines to calculate the Grantham distance
    <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to
    provide a proxy for the evolutionary distance between two amino acids
    based on three key chemical properties: composition, polarity and
    molecular volume. In turn, evolutionary distance is used as a proxy for
    the impact of missense mutations. The higher the distance, the more
    deleterious the substitution is expected to be.
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2
Depends: R (>= 4.1.0)
Imports: tibble, dplyr
URL: https://www.pattern.institute/grantham/,
        https://github.com/patterninstitute/grantham
BugReports: https://github.com/patterninstitute/grantham/issues
Suggests: spelling, testthat (>= 3.0.0)
Language: en-US
Config/Needs/website: rmarkdown, patterninstitute/chic
Config/testthat/edition: 3
NeedsCompilation: no
Packaged: 2025-05-31 21:55:31 UTC; rmagno
Author: Ramiro Magno [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-5226-3441>),
  Isabel Duarte [aut] (ORCID: <https://orcid.org/0000-0003-0060-2936>),
  Ana-Teresa Maia [aut] (ORCID: <https://orcid.org/0000-0002-0454-9207>),
  University of Algarve [fnd],
  CINTESIS [fnd],
  Pattern Institute [cph, fnd] (ROR: <https://ror.org/04jrgd746>)
Maintainer: Ramiro Magno <rmagno@pattern.institute>
Repository: CRAN
Date/Publication: 2025-05-31 22:10:02 UTC
Built: R 4.6.0; ; 2026-04-26 11:19:34 UTC; unix
