Package: dtpcrm
Type: Package
Title: Dose Transition Pathways for Continual Reassessment Method
Version: 0.1.1
Authors@R: c(person("Christina", "Yap", email = "yapchristina17@gmail.com",
                  role = c("aut", "cre")),
             person("Daniel", "Slade", email = "D.Slade@bham.ac.uk",
                  role = c("aut")), 
             person("Kristian", "Brock", email = "k.brock@bham.ac.uk",
                  role = c("aut")),
             person("Yi", "Pan", email = "ypan1988@gmail.com",
                  role = c("aut")))
Maintainer: Christina Yap <yapchristina17@gmail.com>
Description: Provides the dose transition pathways (DTP) to project in advance
    the doses recommended by a model-based design for subsequent patients (stay,
    escalate, deescalate or stop early) using all the accumulated toxicity
    information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP
    can be used as a design and an operational tool and can be displayed as a
    table or flow diagram. The 'dtpcrm' package also provides the modified
    continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with
    added practical considerations to allow stopping early when there is
    sufficient evidence that the lowest dose is too toxic and/or there is a
    sufficient number of patients dosed at the maximum tolerated dose.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
Imports: diagram, dfcrm
Suggests: knitr, rmarkdown, testthat
VignetteBuilder: knitr
RoxygenNote: 6.1.1
NeedsCompilation: no
Packaged: 2019-08-20 09:01:12 UTC; pany
Author: Christina Yap [aut, cre],
  Daniel Slade [aut],
  Kristian Brock [aut],
  Yi Pan [aut]
Repository: CRAN
Date/Publication: 2019-08-20 11:20:02 UTC
Built: R 4.6.0; ; 2026-04-25 18:26:29 UTC; unix
