Package: cobenrich
Type: Package
Title: Using Multiple Continuous Biomarkers for Patient Enrichment in
        Two-Stage Clinical Designs
Version: 1.0.1
Authors@R: c(
    person("Jiangtao", "Gou", email = "gouRpackage@gmail.com", role = c("aut", "cre")),
    person("Fengqing (Zoe)", "Zhang", role = "aut"))
Description: Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers.
    See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.
License: GPL-3
Encoding: UTF-8
Depends: R (>= 4.2.0)
Imports: tmvtnorm (>= 1.2), stats (>= 4.0.0)
RoxygenNote: 7.3.2
NeedsCompilation: no
Packaged: 2025-04-10 15:25:34 UTC; psystat
Author: Jiangtao Gou [aut, cre],
  Fengqing (Zoe) Zhang [aut]
Maintainer: Jiangtao Gou <gouRpackage@gmail.com>
Repository: CRAN
Date/Publication: 2025-04-15 19:30:12 UTC
Built: R 4.6.0; ; 2026-04-26 00:13:11 UTC; unix
