R: Clinical Pharmacokinetics Toolkit

# Clinical Pharmacokinetics Toolkit

## Documentation for package ‘clinPK’ version 0.13.0

- DESCRIPTION file
- Package NEWS
- Package README

## Help Pages

absolute2relative_bsa | Convert quantity expressed in absolute units relative to normalized BSA
accumulation_ratio | Calculate accumulation ratio This is the ratio of drug concentration or AUC at steady state over concentrations after single dose
add_ruv | Add residual variability to data
auc2dose | Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)
calc_abw | Calculate adjusted body weight (ABW)
calc_aki_stage | Calculate AKI stage
calc_amts_for_conc | Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.
calc_baseline_scr | Calculate baseline sCr
calc_bmi | Calculate BMI
calc_bsa | Calculate body surface area
calc_carboplatin_calvert | Calvert equation for carboplatin
calc_creat | Estimate serum creatinine
calc_creat_neo | Estimate serum creatinine in neonates
calc_dosing_weight | Calculate commonly used "dosing weight"
calc_egfr | Calculate eGFR
calc_egfr_cystatin | Calculate eGFR based on Cystatin C measurements
calc_ffm | Calculate fat-free mass
calc_ibw | Calculate ideal body weight in kg for children and adults
calc_kel_double_tdm | Calculate elimination rate when given two TDM samples
calc_kel_single_tdm | Calculate elimination rate when given a single TDM sample
calc_kgfr | Calculate kinetic GFR
calc_lbw | Calculate lean body weight
calc_neutropenia_grade | Calculate neutropenia grade from ANC
calc_t12 | Calculate half-life based on two points
check_covs_available | Checks whether required covariates for eGFR calculations are present
cm2inch | Convert cm to inch
conc2mol | Convert concentration to molar
convert_albumin_unit | Convert albumin from / to units
convert_bilirubin_unit | Convert bilirubin from / to units
convert_creat_assay | Convert serum creatinine from various assays to Jaffe
convert_creat_unit | Convert creatinine to different unit
convert_flow_unit | Convert flow (e.g. clearance) from / to units
dose2auc | Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model
egfr_cov_reqs | Returns parameters needed to calculate eGFR according to the method specified.
find_nearest_dose | Generic function to calculate the dose nearest to a specific dose unit increment
find_nearest_interval | Generic function to calculate the interval nearest to a possible dosing interval
fraction_of_ss | Calculate fraction of steady state at particular time after start of dosing
ibw_devine | Calculate ideal body weight in kg for children and adults
ibw_standard | Calculate ideal body weight in kg for children and adults
inch2cm | Convert inch to cm
kg2lbs | Convert kg to lbs
kg2oz | Convert kg to oz
lbs2kg | Convert lbs to kg
mol2conc | Convert molar to concentration
nca | Perform an NCA based on a NONMEM-style dataset
oz2kg | Convert oz to kg
pct_bmi_for_age | Percentile BMI for age for children
pct_height_for_age | Percentile height for age for children
pct_weight_for_age | Percentile weight for age for children
pk_1cmt_bolus | Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_bolus_cmax_ss | Cmax for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_cmin_ss | Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_dose_from_cmax | Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_dose_from_cmin | Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_ss | Concentration predictions for 1-compartmental PK model with bolus dosing at steady state
pk_1cmt_inf | Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_inf_cmax_ss | Cmax for linear 1-compartment PK model at steady state
pk_1cmt_inf_cmin_ss | Cmin (trough) for linear 1-compartment PK model at steady state
pk_1cmt_inf_dose_for_range | Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model
pk_1cmt_inf_dose_from_cmax | Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_dose_from_cmin | Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_ss | Concentration predictions for 2-compartmental PK model with infusion dosing at steady state
pk_1cmt_oral | Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses
pk_1cmt_t12 | Calculate terminal half-life for 1-compartment model
pk_2cmt_bolus | Concentration predictions for 2-compartmental PK model, single or multiple bolus doses
pk_2cmt_bolus_cmax_ss | Cmax for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_cmin_ss | Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmax | Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmin | Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_ss | Concentration predictions for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf | Concentration predictions for 2-compartmental PK model, single or multiple infusions
pk_2cmt_inf_cmax_ss | Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_cmin_ss | Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_dose_from_cmax | Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_dose_from_cmin | Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_ss | Concentration predictions for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_t12 | Calculate half-life(s) for 2-compartment model
pk_2cmt_t12_interval | Calculate average half-life for 2-compartment model during a specific interval
read_who_table | Read WHO growth tables
relative2absolute_bsa | Convert quantity expressed relative to BSA to absolute units
time_to_ss | Time to steady state In either time units or number of doses
valid_units | Valid units
weight2kg | Convert any weight unit to kg