Package: acmgscaler
Title: Variant Effect Calibration to ACMG/AMP Evidence Strength
Version: 1.0.0
Authors@R: 
    person("Mihaly", "Badonyi", , "mihaly.badonyi@gmail.com",
           role = c("aut", "cre"),
           comment = c(ORCID = "0000-0002-8305-5618"))
Description: Provides a function to calibrate variant effect scores against
    evidence strength categories defined by the American College of Medical
    Genetics and Genomics (ACMG) and the Association for Molecular Pathology
    (AMP) guidelines. The method computes likelihood ratios of pathogenicity
    via kernel density estimation of pathogenic and benign score distributions,
    and derives score intervals corresponding to ACMG/AMP evidence levels. This
    enables researchers and clinical geneticists to interpret functional and
    computational variant scores in a reproducible and standardised manner. For
    details, see Badonyi and Marsh (2025) <doi:10.1093/bioinformatics/btaf503>.
License: MIT + file LICENSE
Encoding: UTF-8
Language: en
Depends: R (>= 3.5.0)
LazyData: true
RoxygenNote: 7.3.2
NeedsCompilation: no
Packaged: 2025-09-18 18:25:42 UTC; mbadonyi
Author: Mihaly Badonyi [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-8305-5618>)
Maintainer: Mihaly Badonyi <mihaly.badonyi@gmail.com>
Repository: CRAN
Date/Publication: 2025-09-23 10:50:08 UTC
Built: R 4.6.0; ; 2026-04-25 15:55:44 UTC; unix
