Package: Surrogate
Type: Package
Title: Evaluation of Surrogate Endpoints in Clinical Trials
Version: 3.4.2
Authors@R: c(
  person("Wim", "Van Der Elst", email = "wim.vanderelst@gmail.com", role = c("cre", "aut")),
  person("Florian", "Stijven", email = "florian.stijven@kuleuven.be", role = "aut"),
  person("Fenny", "Ong", role = "aut"),
  person("Dries", "De Witte", role = "aut"),
  person("Gokce", "Deliorman", role = "aut"),
  person("Paul", "Meyvisch", role = "aut"),
  person("Alvaro", "Poveda", role = "aut"),
  person("Ariel", "Alonso", role = "aut"),
  person("Hannah", "Ensor", role = "aut"),
  person("Christoper", "Weir", role = "aut"),
  person("Geert", "Molenberghs", role = "aut")
  )
Description: In a clinical trial, it frequently occurs that the most credible 
  outcome to evaluate the effectiveness of a new therapy (the true endpoint) is 
  difficult to measure. In such a situation, it can be an effective strategy to 
  replace the true endpoint by a (bio)marker that is easier to measure and that 
  allows for a prediction of the treatment effect on the true endpoint (a 
  surrogate endpoint). The package 'Surrogate' allows for an evaluation of the 
  appropriateness of a candidate surrogate endpoint based on the meta-analytic, 
  information-theoretic, and causal-inference frameworks. Part of this software
  has been developed using funding provided from the European Union's Seventh 
  Framework Programme for research, technological development and demonstration 
  (Grant Agreement no 602552), the Special Research Fund (BOF) of Hasselt 
  University (BOF-number: BOF2OCPO3), GlaxoSmithKline Biologicals, Baekeland 
  Mandaat (HBC.2022.0145), and Johnson & Johnson Innovative Medicine. 
Imports: MASS, lattice, latticeExtra, survival, nlme, lme4, logistf,
        rms, ks, extraDistr, pbapply, flexsurv, rvinecopulib, maxLik,
        purrr, MBESS, tidyr, dplyr, tibble, lifecycle, fastmatrix,
        mratios, Matrix
Depends: R (>= 3.5.0)
License: GPL (>= 2)
Repository: CRAN
NeedsCompilation: no
RoxygenNote: 7.3.3
Encoding: UTF-8
Suggests: copula, FNN, mgcv, testthat (>= 3.0.0), vdiffr, parallel,
        fitdistrplus, kdecopula, cubature, mvtnorm, withr, stringr,
        ggplot2, sn, pracma
Config/testthat/edition: 3
URL: https://github.com/florianstijven/Surrogate-development
BugReports: https://github.com/florianstijven/Surrogate-development/issues
Packaged: 2026-06-03 14:31:11 UTC; wvandere
Author: Wim Van Der Elst [cre, aut],
  Florian Stijven [aut],
  Fenny Ong [aut],
  Dries De Witte [aut],
  Gokce Deliorman [aut],
  Paul Meyvisch [aut],
  Alvaro Poveda [aut],
  Ariel Alonso [aut],
  Hannah Ensor [aut],
  Christoper Weir [aut],
  Geert Molenberghs [aut]
Maintainer: Wim Van Der Elst <wim.vanderelst@gmail.com>
Date/Publication: 2026-06-03 15:00:02 UTC
Built: R 4.6.0; ; 2026-06-03 18:18:02 UTC; unix
