CF_Rsq.measure          Function to calculate the Rsq function as a
                        total effect size measure for mediation effect
                        using cross-fitted estimation
CI.Rsq.measure          Functions to generate the confidence interval
                        of the Rsq measure using nonparametric
                        bootstrap.
Rsq.measure             Function to calculate the Rsq function as a
                        total mediation effect size measure (Gaussian
                        outcome only). If method = 'iSIS', a two-step
                        procedure is performed, where the first step
                        filters the non-mediators based on the first p
                        proportion of the data and the second step
                        calculates the point estimates for Rsq using
                        random-effect models on the remaining data. If
                        method = 'ALL', Rsq is calculated based on all
                        subjects and mediators (assuming all mediators
                        are the true mediators). It is optional to
                        adding filtering step on putative mediators to
                        exclude M1 type of non-mediators (See Yang et
                        al, BMC bioinformatics, 2021).
example                 Example dataset
