Package: ReAD
Type: Package
Title: Powerful Replicability Analysis of Genome-Wide Association
        Studies
Version: 1.0.1
Authors@R: c(person("Yan Li", role = c("aut", "cre", "cph"), email = "yanli_@jlu.edu.cn"), person("Haochen lei", role = c("aut")), person("Xiaoquan Wen", role = c("aut")), person("Hongyuan Cao", role = c("aut")))
Description: A robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.
License: GPL-3
Encoding: UTF-8
Depends: Rcpp (>= 1.0.10), qvalue
LinkingTo: Rcpp, RcppArmadillo
RoxygenNote: 7.2.3
NeedsCompilation: yes
Packaged: 2023-06-28 10:12:42 UTC; P53
Author: Yan Li [aut, cre, cph],
  Haochen lei [aut],
  Xiaoquan Wen [aut],
  Hongyuan Cao [aut]
Maintainer: Yan Li <yanli_@jlu.edu.cn>
Repository: CRAN
Date/Publication: 2023-06-30 11:00:10 UTC
Built: R 4.6.0; aarch64-apple-darwin23; 2026-04-25 21:42:36 UTC; unix
Archs: ReAD.so.dSYM
