R: Power and Sample Size for (Bio)Equivalence Studies

# Power and Sample Size for (Bio)Equivalence Studies

## Documentation for package ‘PowerTOST’ version 1.5-7

- DESCRIPTION file
- User guides, package vignettes and other documentation
- Package NEWS
- Package README

## Help Pages

bib.CL | Design matrices of period balanced incomplete block designs
CI.BE | 1-2*alpha confidence interval given point estimate, CV, and n
CI.RatioF | 1-2*alpha Fieller CI given point estimate, CV (, CVb) and n
CI2CV | CV from a given Confidence interval
ct5.1 | Sample Size Tables for the Classical 2x2 Crossover Design
ct5.2 | Sample Size Tables for the Classical 2x2 Crossover Design
ct5.3 | Sample Size Tables for the Classical 2x2 Crossover Design
ct5.4.1 | Sample Size Tables for the Classical 2x2 Crossover Design
ct9.6.2 | Sample Size Tables for the 2x2x3 Replicate Crossover Design
ct9.6.4 | Sample Size Tables for the 2x4x4 Replicate Crossover Design
ct9.6.6 | Sample Size Tables for the 2x2x3 Replicate Crossover Design
ct9.6.8 | Sample Size Tables for the 2x4x4 Replicate Crossover Design
ctCW.III | Sample Size Tables for the Parallel Group Design
ctSJ.VIII.10 | Sample Size Tables for the Parallel Group Design
ctSJ.VIII.20 | Sample Size Tables for the Parallel Group Design
CV2mse | Helper functions
CV2se | Helper functions
CVCL | Confidence limits of a CV for log-normal data
CVfromCI | CV from a given Confidence interval
CVp2CV | Decompose CV(T) and CV(R) from 'pooled' CV of T/R
CVpooled | Pooled CV from several studies
CVwRfromU | CVwR from the upper expanded limit (ABEL)
data2x2 | Sample Size Tables for the Classical 2x2 Crossover Design
data2x2x3 | Sample Size Tables for the 2x2x3 Replicate Crossover Design
data2x4x4 | Sample Size Tables for the 2x4x4 Replicate Crossover Design
data_parallel | Sample Size Tables for the Parallel Group Design
defunct | Removed functions in PowerTOST
deprecated | Deprecated functions in PowerTOST
exppower.noninf | Expected power of the non-inferiority test
exppower.TOST | Expected power of the TOST procedure
expsampleN.noninf | Sample size based on expected power for the non-inferiority test
expsampleN.TOST | Sample size based on expected power
known.designs | Show the 'known' designs
mse2CV | Helper functions
OwensQ | Owen's Q-function
OwensQOwen | Owen's Q-function via repeated integration by parts
OwensT | Owen's T-function
pa.ABE | Power analysis for average bioequivalence (ABE)
pa.NTID | Power analysis for scaled ABE for NTIDs
pa.NTIDFDA | Power analysis for scaled ABE for NTIDs
pa.scABE | Power analysis for scaled average bioequivalence (scABE)
plot.pwrA | Power analysis for average bioequivalence (ABE)
power.2TOST | Power for two simultaneous TOST procedures
power.dp | Power of dose-proportionality studies evaluated via Power model
power.HVNTID | (Empirical) Power for BE decision via FDA method for highly variable NTIDs
power.noninf | Power of the one-sided non-inferiority t-test
power.NTID | (Empirical) Power for BE decision via FDA method for NTIDs
power.NTIDFDA | (Empirical) Power for BE decision via FDA method for NTIDs
power.RatioF | Power for equivalence of the ratio of two means with normality on original scale
power.RSABE | (Empirical) Power for BE decision via linearized scaled ABE criterion
power.RSABE2L.sds | (Empirical) Power of BE Decision via Reference Scaled ABE
power.RSABE2L.sdsims | (Empirical) Power of BE Decision via Reference Scaled ABE
power.scABEL | (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.scABEL.sds | (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.scABEL.sdsims | (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.TOST | Power of the classical TOST procedure
power.TOST.sds | Power calculation of the BE decision with models incorporating groups
power.TOST.sim | Power of the TOST procedure obtained via simulations
print.CVp | Pooled CV from several studies
print.pwrA | Power analysis for average bioequivalence (ABE)
pvalue.TOST | p-value(s) of the TOST procedure
pvalues.TOST | p-value(s) of the TOST procedure
reg_const | Constructor of an object with class 'regSet' containing the regulatory settings for ABEL
sampleN.2TOST | Sample size based on power of two TOSTs
sampleN.dp | Sample size estimation of dose-proportionality studies evaluated via the power model
sampleN.HVNTID | Sample size estimation for BE decision via FDA method for highly variable (HV) narrow therapeutic index drugs (NTIDs)
sampleN.noninf | Sample size for the non-inferiority t-test
sampleN.NTID | Sample size estimation for BE decision via the FDA's method for narrow therapeutic index drugs (NTIDs)
sampleN.NTIDFDA | Sample size estimation for BE decision via the FDA's method for narrow therapeutic index drugs (NTIDs)
sampleN.RatioF | Sample size for equivalence of the ratio of two means with normality on original scale
sampleN.RSABE | Sample size estimation for BE decision via linearized scaled ABE criterion
sampleN.RSABE2L.sds | Sample size estimation for BE Decision via Reference Scaled ABE
sampleN.RSABE2L.sdsims | Sample size estimation for BE Decision via Reference Scaled ABE
sampleN.scABEL | Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.scABEL.ad | Sample size estimation for ABEL and iteratively adjusted alpha
sampleN.scABEL.sds | Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.scABEL.sdsims | Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.TOST | Sample size based on power of TOST
scABEL | Scaled (widened) BE Acceptance Limits
scABEL.ad | Iteratively adjusted alpha for ABEL
se2CV | Helper functions
type1error.2TOST | Type I error rate for two simultaneous TOST procedures
U2CVwR | CVwR from the upper expanded limit (ABEL)