{
  "id": "pk_vanco_germovsek",
  "ode_code": "\
    dAdt[0] = -(CLi / Vi) * A[0];\
    dAdt[1] = (A[0]/Vi);",
  "pk_code": "\
    HILL = 3.33\
    TM50 = 55.4\
    Fallo = pow((WT/70.0), 0.632)\
    Fmat = pow(PMA, HILL) / (pow(TM50, HILL) + pow(PMA, HILL))\
    CLi = CL * Fallo * Fmat + CL_HEMO\
    Vi =  V * (WT/70.0)",
  "n_comp": 2,
  "obs": {
    "cmt": 1,
    "scale": "V * (WT/70.0)"
  },
  "dose": {
    "cmt": 1,
    "bioav": 1
  },
  "parameters": {
    "CL": 5.7329,
    "V": 39.26
  },
  "fixed": [],
  "omega_matrix": [
    0.103194,
    0.0444473,
    0.0999011
  ],
  "iov": null,
  "ruv": {
    "prop": 0.2965,
    "add": 0.001
  },
  "covariates": [
    "WT",
    "PMA",
    "CL_HEMO"
  ],
  "variables": [
    "Fallo",
    "Fmat",
    "CLi",
    "Vi",
    "HILL",
    "TM50"
  ],
  "misc": {
    "model_type": "1cmt_iv",
    "linearity": "linear",
    "init_parameter": true
  },
  "references": [
    {
      "ref": "Germovsek E et al. JAC 2019",
      "url": "https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dky525/5298179"
    }
  ],
  "version": "0.2.4"
}
