Package: MPGE
Type: Package
Title: A Two-Step Approach to Testing Overall Effect of
        Gene-Environment Interaction for Multiple Phenotypes
Version: 1.0.1
Date: 2026-03-09
Authors@R: c(person("Arunabha", "Majumdar", email = "statgen.arunabha@gmail.com", role = c("aut", "cre")), person("Tanushree", "Haldar", email = "tanushree.haldar@gmail.com", role = "aut"))
Maintainer: Arunabha Majumdar <statgen.arunabha@gmail.com>
Description: Interaction between a genetic variant (e.g., a single nucleotide polymorphism) and an environmental variable (e.g., physical activity) can have a shared effect on multiple phenotypes (e.g., blood lipids). We implement a two-step method to test for an overall interaction effect on multiple phenotypes. In first step, the method tests for an overall marginal genetic association between the genetic variant and the multivariate phenotype. The genetic variants which show an evidence of marginal overall genetic effect in the first step are prioritized while testing for an overall gene-environment interaction effect in the second step. Methodology is available from: A Majumdar, KS Burch, T Haldar, S Sankararaman, B Pasaniuc, WJ Gauderman, JS Witte (2020) <doi:10.1093/bioinformatics/btaa1083>.
Depends: R (>= 3.5.0)
License: GPL-3
Encoding: UTF-8
LazyData: true
URL: https://github.com/ArunabhaCodes/MPGE
BugReports: https://github.com/ArunabhaCodes/MPGE/issues
RoxygenNote: 7.3.3
Suggests: knitr, rmarkdown, spelling, testthat (>= 3.0.0)
VignetteBuilder: knitr
Imports: car, purrr, stats, utils
Config/testthat/edition: 3
Language: en-US
NeedsCompilation: no
Packaged: 2026-03-12 04:03:13 UTC; arunabha
Author: Arunabha Majumdar [aut, cre],
  Tanushree Haldar [aut]
Repository: CRAN
Date/Publication: 2026-03-12 08:20:50 UTC
Built: R 4.6.0; ; 2026-04-25 14:04:57 UTC; unix
