Package: GEVACO
Type: Package
Title: Joint Test of Gene and GxE Interactions via Varying Coefficients
Version: 1.0.1
Author: Zhengyang Zhou [aut]
        Sydney Manning [aut, cre]
        Chao Xing [aut]
        Hung-Chih Ku [aut]
Depends: R (>= 3.6)
Description: A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.
License: GPL-3
Encoding: UTF-8
LazyData: true
Imports: nlme, RLRsim, stats
Suggests: rmarkdown, knitr
RoxygenNote: 7.1.2
VignetteBuilder: knitr
Maintainer: Sydney Manning <sydney.manning@unthsc.edu>
NeedsCompilation: no
Packaged: 2021-12-08 17:43:36 UTC; Student
Repository: CRAN
Date/Publication: 2021-12-10 12:10:05 UTC
Built: R 4.6.0; ; 2026-04-26 07:38:56 UTC; unix
