Package: DANDELION
Type: Package
Title: Discovery of Candidate Disease Genes Using Trans-Regulatory
        Effects
Version: 0.1.0
Authors@R: 
    person(
        given = "Peixin",
        family = "Tian",
        role = c("aut", "cre"),
        email = "pxtian@connect.hku.hk"
    )
Description: Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) <doi:10.1080/01621459.2021.1914634>. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.3
Imports: igraph
Suggests: qvalue
Additional_repositories: https://bioconductor.org/packages/release/bioc
NeedsCompilation: no
Packaged: 2026-04-30 07:05:09 UTC; px
Author: Peixin Tian [aut, cre]
Maintainer: Peixin Tian <pxtian@connect.hku.hk>
Repository: CRAN
Date/Publication: 2026-05-04 19:20:09 UTC
Built: R 4.6.0; ; 2026-05-04 22:06:46 UTC; unix
