R: Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials

# Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials

## Documentation for package ‘BOIN’ version 2.7.2

- DESCRIPTION file

## Help Pages

get.boundary | Generate the optimal dose escalation and deescalation boundaries for conducting the trial.
get.oc | Generate operating characteristics for single agent trials
get.oc.comb | Generate operating characteristics for drug combination trials
next.comb | Determine the dose combination for the next cohort of new patients for drug-combination trials that aim to find a MTD
next.subtrial | Determine the starting dose and the dose-searching space for next subtrial in waterfall design
plot.boin | Plot the flowchart and simulation results for BOIN designs
print.boin | Generate descriptive summary for objects returned by other functions
select.mtd | Select the maximum tolerated dose (MTD) for single agent trials
select.mtd.comb | Select the maximum tolerated dose (MTD) or MTD contour for drug combination trials
summary.boin | Generate descriptive summary for objects returned by other functions