check_ae_aeacn_ds_disctx_covid
                        Check for COVID-19 AE with DRUG WITHDRAWN
                        action without "ADVERSE EVENT" for DS Trt
                        Discon
check_ae_aeacnoth       Check for null AEACNOT1/2 when AEACNOTH =
                        'MULTIPLE'
check_ae_aeacnoth_ds_disctx
                        Check if, whenever a patient experiences an AE
                        leading to study discontinuation, they also
                        have a DS record indicating this.
check_ae_aeacnoth_ds_stddisc_covid
                        Check for COVID-19 AE leading to Study Discon
                        without DS Study Discon
check_ae_aedecod        Check for missing AEDECOD values
check_ae_aedthdtc_aesdth
                        Check AEs with AEDTHDTC value but AESDTH not
                        "Y"
check_ae_aedthdtc_ds_death
                        Check for missing AEDTHDTC where DS indicates
                        death due to AE
check_ae_aelat          Check if AESOC has Eye, and Affected Eye is
                        missing
check_ae_aeout          Check for inconsistency between AE outcome
                        (AEOUT) and death date (AEDTHDTC)
check_ae_aeout_aeendtc_aedthdtc
                        Check for AE outcome (AEOUT) of 'FATAL' with
                        non-missing resolution date that is not equal
                        to the death date
check_ae_aeout_aeendtc_nonfatal
                        Check for non-fatal AEs with inconsistent AEOUT
                        and AEENDTC
check_ae_aerel          Check for AEREL1 - AERELN when AEREL is missing
                        and when AEREL is unexpected
check_ae_aesdth_aedthdtc
                        Check AEs with AESDTH of "Y" but No AEDTHDTC
                        Value
check_ae_aestdtc_after_aeendtc
                        Check that all AE start dates are on or before
                        AE end dates
check_ae_aestdtc_after_dd
                        Check for AE dates occurring after death date
check_ae_aetoxgr        Check for missing AETOXGR and/or AESEV values
check_ae_death          Check for Grade 5 AE death variable consistency
check_ae_death_ds_discon
                        Check if death in AE then there should be a
                        study discon form
check_ae_ds_partial_death_dates
                        Check for partial death dates in AE and DS
check_ae_dup            Check for duplicate AE entries
check_ae_fatal          Check for death variable consistency when
                        AEOUT=="FATAL"
check_ae_withdr_ds_discon
                        Check if an AE leading to drug being withdrawn
                        is reflected in DS
check_ce_missing_month
                        Check for clinical events dates with year and
                        day known but month unknown
check_cm_cmdecod        Check for missing CMDECOD values
check_cm_cmindc         Check for concomitant medication indication
                        with text string "PROPHYL" when not given for
                        prophylaxis
check_cm_cmlat          Check if ocular concomitant medication has
                        laterality missing or laterality field is
                        populated but route is not eye-related.
check_cm_cmlat_prior_ocular
                        Check if ocular concomitant medication has
                        laterality missing for specific "PRIOR OCULAR
                        THERAPIES AND TREATMENTS" (or similar names)
                        CRF page.
check_cm_missing_month
                        Check for conmed dates with year and day known
                        but month unknown
check_dd_ae_aedthdtc_ds_dsstdtc
                        Check if death date is the same in AE and DS
                        domains
check_dd_ae_aeout_aedthdtc
                        Check if there is a death date and
                        AEOUT='FATAL' agreement
check_dd_death_date     Check if patient with Death due to AE also has
                        Death record in DS
check_dm_actarm_arm     Check DM where ARM is not equal to ACTARM
check_dm_ae_ds_death    Check if death reported in DM then death
                        indicator also present in DS or AE
check_dm_age_missing    Check for patients with suspicious age values
check_dm_armcd          Check for missing ARM or ARMCD values in DM
check_dm_dthfl_dthdtc   Check that when DM.DTHFL is Y, DM.DTHDTC does
                        not have a missing value, and vice versa
check_dm_usubjid_ae_usubjid
                        Check patients in the DM dataset who do not
                        have records in the AE dataset
check_dm_usubjid_dup    Check duplicate patient records in DM based on
                        USUBJID
check_ds_ae_discon      Check for treatment discontinuation consistency
                        between DS and AE
check_ds_dsdecod_death
                        Check for study discontinuation record if death
                        indicated
check_ds_dsdecod_dsstdtc
                        Check DS with death record but no death date
check_ds_dsscat         Check for patients with more than one study
                        discontinuation records
check_ds_dsterm_death_due_to
                        Check missing cause of death information in DS
check_ds_duplicate_randomization
                        Check for duplicate randomization records for a
                        patient
check_ds_ex_after_discon
                        Check for patients who had Start/End date of
                        treatment after study discontinuation date
check_ds_multdeath_dsstdtc
                        Check DS with multiple death records with death
                        dates, where death dates do not match
check_ds_sc_strat       Check if randomized patients are missing
                        stratification factor data
check_dv_ae_aedecod_covid
                        Check for consistency between DV and AE for
                        COVID-19 events
check_dv_covid          Check for consistency in COVID-19 DV variables,
                        DVREAS and DVEPRELI
check_ec_sc_lat         Check if Study Drug is not administered in the
                        Study Eye
check_eg_egdtc_visit_ordinal_error
                        Check that all ECG datetimes are earlier than
                        last visit's (possible datetime data entry
                        error)
check_ex_dup            Check for duplicate EX records
check_ex_exdose_exoccur
                        Check for Missing EXDOSE.
check_ex_exdose_pos_exoccur_no
                        Check for EXDOSE>0 When EXOCCUR is not "Y"
check_ex_exdosu         Check for missing EXDOSU records
check_ex_exoccur_exdose_exstdtc
                        Check for Invalid EXDOSE (Dose per
                        Administration) and Missing/Incomplete EXSTDTC
                        (Start Date) Values for valid exposures
check_ex_exoccur_mis_exdose_nonmis
                        Check for missing EXOCCUR but EXDOSE not
                        missing
check_ex_exstdtc_after_dd
                        Check for EX dates occurring after death date
check_ex_exstdtc_after_exendtc
                        Check that all exposure start dates are on or
                        before exposure end dates
check_ex_exstdtc_visit_ordinal_error
                        Check that all EX start dates are earlier than
                        last visit's (possible datetime data entry
                        error)
check_ex_extrt_exoccur
                        Check for EX records where EXTRT is missing
check_ex_infusion_exstdtc_exendtc
                        Check that an infusion drug has same start/end
                        exposure dates, also including missing
                        start/end dates
check_ex_visit          Check for missing EX.VISIT
check_lb_lbdtc_after_dd
                        Check for LB dates occurring after death date
check_lb_lbdtc_visit_ordinal_error
                        Check that all LB dates are duplicated or
                        earlier than last visit's (possible datetime
                        data entry error)
check_lb_lbstnrlo_lbstnrhi
                        Check for missing lab reference ranges
                        (LBSTNRLO, LBSTNRHI)
check_lb_lbstresc_char
                        Check LBORRES/LBSTRESC populated with number
                        beginning with character '>' or '<', which will
                        yield missing AVAL in ADaM and records will be
                        omitted in analyses such as Hy's Law
check_lb_lbstresn_missing
                        Check missing standard lab values
                        (LBSTRESN/LBSTRESC)
check_lb_lbstresu       Check for missing lab units (LBSTRESU)
check_lb_missing_month
                        Check for lab dates with year and day known but
                        month unknown
check_mh_missing_month
                        Check for MH dates with year and day known but
                        month unknown
check_mi_mispec         Check for missing values in the MISPEC variable
check_oe_bcva_1m_late_early_tot
                        Check if 1m BCVA test stops too late, too early
                        and has correct total
check_oe_bcva_4m_late_early_tot
                        Check if 4m BCVA test stops too late, too early
                        and has correct total
check_oe_bcva_4m_vs_1m_req
                        Check if 1m BCVA test is completed per BCVA 4m
                        result
check_oe_bcva_tot_mismatch
                        Check mismatch between Derived BCVA Total Score
                        & Total BCVA Score from Data
check_oe_sc_lat_count_fingers
                        Check if Post Treatment Count Fingers in Study
                        Eye laterality does not match with Subject
                        Characteristics Study Eye laterality
check_pr_missing_month
                        Check for procedure dates with year and day
                        known but month unknown
check_pr_prlat          Check if ocular procedures/surgeries has
                        laterality missing for CRF pages which contain
                        the word "OCULAR" (and not "NON-OCULAR").
check_qs_dup            Check for multiple dates at the same visit in
                        QS
check_qs_qsdtc_after_dd
                        Check for QS dates occurring after death date
check_qs_qsdtc_visit_ordinal_error
                        Check that all QS dates are duplicated or
                        earlier than last visit's (possible datetime
                        data entry error)
check_qs_qsstat_qsreasnd
                        Check to confirm that there is a reason for a
                        questionnaire being marked as not done
check_qs_qsstat_qsstresc
                        Check for non-missing QSSTRESC if QSSTAT is NOT
                        DONE
check_rs_rscat_rsscat   Check for patients with populated RSSCAT but
                        missing RSCAT.
check_rs_rsdtc_across_visit
                        Check RS records where the same date occurs
                        across multiple visits
check_rs_rsdtc_visit    Check missing RSDTC and VISIT
check_rs_rsdtc_visit_ordinal_error
                        Check that all RS dates for INV Overall
                        Response are duplicated or earlier than last
                        visit's (possible date entry error)
check_sc_dm_eligcrit    Check SC Eye Meeting Eligibility Criteria
                        assignments among DM patients
check_sc_dm_seyeselc    Check SC Study Eye Selection assignments among
                        DM patients
check_ss_ssdtc_alive_dm
                        Check non-missing last ALIVE status date in SS
                        is before than death date in DM
check_ss_ssdtc_dead_ds
                        Check non-missing DEAD status date in SS and
                        non-missing according DS record with death date
                        where status date is greater or equal to death
                        date
check_ss_ssdtc_dead_dthdtc
                        Check non-missing DEAD status date in SS and an
                        according DM record with death date where
                        status date is greater or equal to death date
check_ss_ssstat_ssorres
                        Check for non-missing SSORRES if SSSTAT is NOT
                        DONE
check_tr_dup            Check for duplicate TR records
check_tr_trdtc_across_visit
                        Check TR Longest Diameter Records where the
                        same date occurs across multiple visits
check_tr_trdtc_visit_ordinal_error
                        Check that all TR dates by INV are duplicated
                        or earlier than last visit's (possible date
                        entry error)
check_tr_trstresn_ldiam
                        Check for TR records with missing TRSTRESN for
                        Longest Diameter (LDIAM)
check_ts_aedict         Check for missing MedDRA version in TS
check_ts_cmdict         Check for missing WHODrug version in TS
check_ts_sstdtc_ds_consent
                        Check for missing SSTDTC (Study Start Date) in
                        TS
check_tu_rs_new_lesions
                        Check for consistency between new lesions and
                        overall PD response
check_tu_tudtc          Check for missing TUDTC values
check_tu_tudtc_across_visit
                        Check TU Records where the same date occurs
                        across multiple visits
check_tu_tudtc_visit_ordinal_error
                        Check that all TU dates are duplicated or
                        earlier than last visit's (possible datetime
                        data entry error)
check_tu_tuloc_missing
                        Check for missing TULOC values
check_vs_height         Check for missing height values
check_vs_sbp_lt_dbp     Check that DBP is not higher than SBP in VS
check_vs_vsdtc_after_dd
                        Check for VS dates occurring after death date
create_R_script         Create .R file with sdtmchecks function calls
diff_reports            Create a sdtmchecks list object with column
                        indicating whether the issue was previously
                        seen
run_all_checks          Run all data checks in sdtmchecks package using
                        parallel processing
run_check               Run a single check in sdtmchecks package
sdtmchecksmeta          Metadata for sdtmchecks
