Package: pkpd.Release
Type: Package
Title: Model Fitting and Simulation for Drug Release Kinetics and PK/PD
Version: 0.1.0
Author: Paul Angelo C. Manlapaz [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-1203-2064>)
Maintainer: Paul Angelo C. Manlapaz <pacmanlapaz@gmail.com>
Description: Provides a comprehensive framework for model fitting and simulation
    of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD).
    The package implements widely used mechanistic and empirical models for in
    vitro drug release, including zero-order, first-order, Higuchi,
    Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic
    functionality includes linear and nonlinear functions for one- and
    two-compartment models for intravenous bolus and oral administration,
    Michaelis-Menten kinetics, and non-compartmental analysis (NCA).
    Pharmacodynamic and dose-response modeling is supported through Emax-based
    models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax)
    Hill models, four- and five-parameter logistic models, as well as median
    toxic dose (TD50) and lethal dose (LD50) models. The package is intended to
    support parameter estimation, simulation, and model comparison in
    pharmaceutical research, drug development, and pharmacometrics education.
    For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>,
    Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and
    Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.
License: GPL-3
Encoding: UTF-8
Depends: R (>= 4.1.0)
Imports: stats, ggplot2, minpack.lm, gridExtra, scales
Suggests: testthat (>= 3.0.0), knitr, rmarkdown
Config/testthat/edition: 3
RoxygenNote: 7.3.2
Authors@R: 
    c(person(given = "Paul Angelo C.",
             family = "Manlapaz",
             role = c("aut", "cre"),
             email = "pacmanlapaz@gmail.com",
             comment = c(ORCID = "0000-0002-1203-2064")))
NeedsCompilation: no
Packaged: 2026-01-22 09:48:28 UTC; PTRI
Repository: CRAN
Date/Publication: 2026-01-27 08:40:02 UTC
Built: R 4.6.0; ; 2026-04-28 08:27:38 UTC; unix
