Package: phase12designs
Type: Package
Title: Comprehensive Tools for Running Model-Assisted Phase I/II Trial
        Simulations
Version: 0.3.1
Authors@R: c(person(given = "Angela", family = "Cao", role = c("aut", "cre"), email = "cao.t.angela@gmail.com"),
    person(given = "Haolun", family = "Shi", role = "ctb"))
Author: Angela Cao [aut, cre],
  Haolun Shi [ctb]
Maintainer: Angela Cao <cao.t.angela@gmail.com>
Description: Provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including:
  - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <doi:10.1200/PO.20.00257>),
  - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <doi:10.1002/pst.1864>),
  - EffTox (Thall, P. F., & Cook, J. D. (2004) <doi:10.1111/j.0006-341X.2004.00218.x>),
  - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <doi:10.1080/10543406.2020.1818250>),
  - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) <doi:10.1177/0962280220977009>),
  - STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) <doi:10.1002/sim.7428>),
  - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>),
  - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) <doi:10.1002/sim.8922>).
 Includes flexible simulation parameters that allow
 researchers to efficiently compute operating characteristics under
 various fixed and random trial scenarios and export the results.
License: MIT + file LICENSE
Encoding: UTF-8
Imports: trialr, Iso
Suggests: knitr, rmarkdown
VignetteBuilder: knitr
RoxygenNote: 7.3.2.9000
NeedsCompilation: no
Packaged: 2025-08-27 21:35:29 UTC; angela
Repository: CRAN
Date/Publication: 2025-09-02 06:30:02 UTC
Built: R 4.6.0; ; 2026-04-29 23:58:10 UTC; unix
