# mixtox
**Dose-Response Curve Fitting and Mixture Toxicity Assessment**
### Description
* Curve Fitting for monotonic(sigmoidal) & non-monotonic(J-shaped) 
concentration-response data. Prediction of mixture toxicity based on reference 
models such as 'concentration addition', 'independent action', and 'generalized 
concentration addition'.
* Source: https://cran.r-project.org/web/packages/mixtox/index.html
* Manual: https://cran.r-project.org/web/packages/mixtox/mixtox.pdf

* Version: 1.4.1
* Date: 2026-04-17
* License: GPL-2
### Keywords
* mixture toxicity
* goodness of fit
* sigmoidal dose-response curve
* non-monotonic dose-response curve
* curve fitting
* concentration addition
* independent action
* generalized concentration addition
### Introduction
* Curve fitting of concentration-responses based on 13 monotonic(sigmoidal) and 4 
non-monotonic(J-shaped) models, goodness of fit, and calculation of confidence interval 
* Experimental design for mixture toxicity
  * acr: arbitrary concentration ratio
  * eecr: equal effect concentration ratio
  * udcr: uniform design concentration ratio
* Mixture toxicity prediction based on reference models such as concentration addition (CA), 
	independent action (IA), and generalized concentration addition (GCA).

### References
* Zhu, X.-W., Chen, J.-Y. (2016). mixtox: An R Package for Mixture Toxicity Assessment. 
R Journal, 8(2), 422-434.
* Zhu, X.-W., Ge, H.-L., Cao, Y.-B. (2016). Mixture cytotoxicity assessment of ionic liquids 
and heavy metals in MCF-7 cells using mixtox. Chemosphere, 163, 544-551.
* Zhu X-W, Liu S-S, Qin L-T, Chen F, Liu H-L. 2013. Modeling non-monotonic dose-response 
relationships: Model evaluation and hormetic quantities exploration. Ecotoxicology and 
Environmental Safety 89:130-136.
