Package: hscovar
Type: Package
Title: Calculation of Covariance Between Markers for Half-Sib Families
Version: 0.4.2
Date: 2021-04-13
Authors@R: c(person("Dörte","Wittenburg", role = c("aut", "cre"), 
    email = "wittenburg@fbn-dummerstorf.de"),
    person("Michael", "Doschoris", role = "aut"),
    person("Jan", "Klosa", role = "ctb"))
Description: The theoretical covariance between pairs of markers is calculated
    from either paternal haplotypes and maternal linkage disequilibrium (LD) or 
    vise versa. A genetic map is required. Grouping of markers is based on the 
    correlation matrix and a representative marker is suggested for each group.
    Employing the correlation matrix, optimal sample size can be derived for 
    association studies based on a SNP-BLUP approach.
    The implementation relies on paternal half-sib families and biallelic 
    markers. If maternal half-sib families are used, the roles of sire/dam are 
    swapped. Multiple families can be considered.
    Wittenburg, Bonk, Doschoris, Reyer (2020) "Design of Experiments for 
    Fine-Mapping Quantitative Trait Loci in Livestock Populations" 
    <doi:10.1186/s12863-020-00871-1>.
    Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004) "Selecting a 
    maximally informative set of single-nucleotide polymorphisms for association
    analyses using linkage disequilibrium" <doi:10.1086/381000>.
Depends: R (>= 3.5.0)
Imports: parallel, Matrix, foreach, rlist, pwr
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.1
NeedsCompilation: no
Packaged: 2021-04-13 06:30:46 UTC; wittenburg
Author: Dörte Wittenburg [aut, cre],
  Michael Doschoris [aut],
  Jan Klosa [ctb]
Maintainer: Dörte Wittenburg <wittenburg@fbn-dummerstorf.de>
Repository: CRAN
Date/Publication: 2021-04-13 07:20:06 UTC
Built: R 4.6.0; ; 2026-04-27 10:03:31 UTC; unix
