R: Adaptive Enrichment Designs with Sample Size Re-Estimation

# Adaptive Enrichment Designs with Sample Size Re-Estimation

## Documentation for package ‘esDesign’ version 1.0.3

- DESCRIPTION file
- Package NEWS

## Help Pages

AED.boundary | Calculate the critical value used at the final analysis in AED
AED.sim | Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundary
AED1_SSR.boundary | Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure
AED1_SSR.CP | Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation Procedure
AED1_SSR.N2 | Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation Procedure
AED1_SSR.sim | Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure
AED2_SSR.boundary | Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED2_SSR.CP | Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED2_SSR.sim | Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED3_SSR.boundary | Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpoint
AED3_SSR.CP | Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure
AED3_SSR.sim | Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpoint
MaST.sim | Conduct the simulation studies of the Marker Sequential Test design
SD.sim | Conduct the simulation studies of the standard design
SigP | Commonly used alpha-spending functions
sSize.norm | Sample size calculation for the standard design with continuous endpoint
SSR.boundary | Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error function
SSR.CP | Calculate the N2 and the critical value C in Sample Size Re-estimation Procedure
SSR.sim | Conduct the simulation studies using SSR