Package: esDesign
Type: Package
Title: Adaptive Enrichment Designs with Sample Size Re-Estimation
Version: 1.0.3
Date: 2021-07-13
Author: Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan
Maintainer: Zhao Yang <yangz98@connect.hku.hk>
Description: Software of 'esDesign' is developed to implement the adaptive 
    enrichment designs with sample size re-estimation presented in 
    Lin et al. (2021) <doi: 10.1016/j.cct.2020.106216>. In details, 
    three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR),
    AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package 
    also contains several widely used adaptive designs, such as the Marker 
    Sequential Test (MaST) design proposed Freidlin et al. 
    (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs 
    without early stopping (AED or ES), the sample size re-estimation 
    procedure (SSR) based on the conditional power proposed by 
    Proschan and Hunsberger (1995), and some useful functions. 
    In details, we can calculate the futility and/or efficacy stopping 
    boundaries, the sample size required, calibrate the value of the threshold 
    of the difference between subgroup-specific test statistics, conduct the 
    simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.
Depends: R (>= 3.2.0)
Imports: stats
License: GPL-2
Encoding: UTF-8
LazyData: false
RoxygenNote: 7.1.1
Suggests: knitr, rmarkdown
NeedsCompilation: no
Packaged: 2021-07-13 05:38:25 UTC; Yang Zhao
Repository: CRAN
Date/Publication: 2021-07-13 05:50:02 UTC
Built: R 4.6.0; ; 2026-04-26 17:31:50 UTC; unix
