R: Phase I/II CRM Based Drug Combination Design

# Phase I/II CRM Based Drug Combination Design

## Documentation for package ‘crm12Comb’ version 0.1.12

- DESCRIPTION file
- User guides, package vignettes and other documentation

## Help Pages

doseComb_to_mat | Title: Get 6 complete orderings for toxicity and efficacy for drug combinations
efficacy_est | Efficacy estimation
empiric_GammaPriorLikelihood | empiric model with gamma prior
empiric_NormalPriorLikelihood | empiric model with normal prior
enroll_patient_plot | Plot patient enrollment for single trial
examples_results | Output dataset for examples given list of inputs
get_ordering | Complete orderings for combinations of two drugs
logisticOnePara_GammaPriorLikelihood | one-parameter logistic model with gamma prior
logisticOnePara_NormalPriorLikelihood | one-parameter logistic model with normal prior
logisticTwoPara_GammaPriorLikelihood | two-parameter logistic model with gamma prior
logisticTwoPara_NormalPriorLikelihood | two-parameter logistic model with normal prior
maximization_phase | Maximization phase
ODC_plot | Plot optimal combination dose selections
patient_allocation_plot | Plot patient allocation for a single trial
priorSkeletons | Generate the skeletons of toxicity and efficacy
randomization_phase | Adaptive randomization
rBin2Corr | Generate correlated binary variables
sample_plot | Sample plot for a given output results
SIM_phase_I_II | Single simulation of phase I/II adaptive design for drug combinations based on CRM design
tanh_ExpPriorLikelihood | Title: Bayesian likelihood inference
toxicity_est | Toxicity estimation