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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling" Data-Source="WikiPathways" Version="WP3850_r121711" Author="[AlexanderPico, Mkutmon, Khanspers, Fehrhart, Eweitz]" Last-Modified="20220226045156" Organism="Homo sapiens">
  <Comment Source="WikiPathways-description">The signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth. The kinase Akt, or protein kinase B (PKB), is a central component in the pathway and is involved in both muscle synthesis, through mammalian target of rapmycin (mTOR) and glycogen synthase kinase 3B (GSK3B), and muscle degradation, through the transcription factors of the FoxO family. The pathway also involves several feedback loops such as the negative feedback of S6K, phosphorylated by mTORC1, which  inhibits IRS, or the positive feedback of mTORC2, which is necessary to maximize the activation of Akt. A variety of other factors and pathways also influence the IGF1-Akt signaling pathway at various points.

Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3850 CPTAC Assay Portal]</Comment>
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    <Comment>phosphatidlinositol 3-kinase</Comment>
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    <Comment>TRIM63</Comment>
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    <Comment>not sure, because also 2, 3, 4</Comment>
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      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000238</bp:ID>
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
    </bp:openControlledVocabulary>
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a03">
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21798082</bp:ID>
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.</bp:TITLE>
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Skelet Muscle</bp:SOURCE>
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schiaffino S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mammucari C</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>
