# ParCC Tutorial Index

## ParCC Vignette Library

ParCC (Parameter Converter & Calculator) provides a comprehensive set of tutorials organized by topic. Each vignette includes realistic clinical scenarios, worked examples with R code, and references to the underlying methodology.

### Getting Started

- `vignette("getting-started")` – Installation, launching the app, and the Lab Notebook workflow

### Core Conversions

- `vignette("core-conversions")` – Rate to Probability, Odds to Probability, and Time Rescaling with real-world examples from the RE-LY trial and UKPDS Risk Engine

### Hazard Ratio Conversion (NEW in v1.3.0)

- `vignette("hr-probability-converter")` – Converting control group probabilities to intervention probabilities using Hazard Ratios. Includes worked examples from the PLATO trial (Ticagrelor vs Aspirin) and oncology models.

### Survival Extrapolation

- `vignette("survival-extrapolation")` – Fitting Exponential and Weibull survival curves from published Kaplan-Meier data when IPD is unavailable

### Background Mortality

- `vignette("background-mortality")` – SMR adjustment, DEALE, Gompertz parameterization, and linear interpolation for adjusting census life tables to disease-specific cohorts

### Probabilistic Sensitivity Analysis

- `vignette("psa-distributions")` – Fitting Beta (utilities), Gamma (costs), and LogNormal (HRs) distributions using the Method of Moments. Includes the Rule of 4 approximation.

### Economic Evaluation

- `vignette("economic-evaluation")` – ICER calculation, Net Monetary Benefit, and Value-Based Pricing (Headroom Analysis) with Indian HTA context

### Batch Processing

- `vignette("batch-workflow")` – Uploading CSV files for bulk conversion, including the new HR-based batch conversion

## Key References

- Sonnenberg FA, Beck JR. Markov models in medical decision making. Med Decis Making. 1993;13(4):322-338.
- Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation. Oxford University Press; 2006.
- Collett D. Modelling Survival Data in Medical Research. 3rd ed. Chapman and Hall/CRC; 2015.
- Drummond MF, et al. Methods for the Economic Evaluation of Health Care Programmes. 4th ed. Oxford University Press; 2015.
- Cosh E, et al. The value of ‘innovation headroom’. Value in Health. 2007;10(4):312-315.
- NICE DSU. Technical Support Document 14: Survival analysis for economic evaluations. 2013.