R: Design and Monitoring of Survival Trials Accounting for Complex Situations

# Design and Monitoring of Survival Trials Accounting for Complex Situations

## Documentation for package ‘PWEALL’ version 1.3.0.1

- DESCRIPTION file

## Help Pages

PWEALL-package | Design and Monitoring of Survival Trials Accounting for Complex Situations
cp | Conditional power given observed log hazard ratio
cpboundary | The stopping boundary based on the conditional power criteria
cpstop | The stopping probability based on the stopping boundary
fourhr | A utility functon
hxbeta | A function to calculate the beta-smoothed hazard rate
innercov | A utility function to calculate the inner integration of the overall covariance
innervar | A utility function to calculate the inner integration of the overall variance
instudyfindt | calculate the timeline in study when some or all subjects have entered
ovbeta | calculate the overall log hazard ratio
overallcov | calculate the overall covariance
overallcovp1 | calculate the first part of the overall covariance
overallcovp2 | calculate the other parts of the overall covariance
overallvar | calculate the overall variance
pwe | Piecewise exponential distribution: hazard, cumulative hazard, density, distribution, survival
PWEALL | Design and Monitoring of Survival Trials Accounting for Complex Situations
pwecx | Various function for piecewise exponential distribution with crossover effect
pwecxcens | Integration of the density of piecewise exponential distribution with crossover effect and the censoring function
pwecxpwu | Integration of the density of piecewise exponential distribution with crossover effect, censoring and recruitment function
pwecxpwufindt | calculate the timeline when certain number of events accumulates
pwecxpwuforvar | calculate the utility function used for varaince calculation
pwefv2 | A utility function
pwefvplus | A utility functon
pwepower | Calculating the powers of various the test statistics for superiority trials
pwepowereq | Calculating the powers of various the test statistics for equivalence trials
pwepowerfindt | Calculating the timepoint where a certain power of the specified test statistics is obtained
pwepowerni | Calculating the powers of various the test statistics for non-inferiority trials
pwesim | simulating the test statistics
pwu | Piecewise uniform distribution: distribution
qpwe | Piecewise exponential distribution: quantile function
qpwu | Piecewise uniform distribution: quantile function
rmstcov | Calculation of the variance and covariance of estimated restricted mean survival time
rmsth | Estimate the restricted mean survival time (RMST) and its variance from data
rmstpower | Calculate powers at different cut-points based on difference of restricted mean survival times (RMST)
rmstpowerfindt | Calculating the timepoint where a certain power of mean difference of RMSTs is obtained
rmstsim | simulating the restricted mean survival times
rmstutil | A utility function to calculate the true restricted mean survival time (RMST) and its variance account for delayed treatment, discontinued treatment and non-uniform entry
rpwe | Piecewise exponential distribution: random number generation
rpwecx | Piecewise exponential distribution with crossover effect: random number generation
rpwu | Piecewise uniform distribution: random number generation
spf | A utility function
wlrcal | A utility function to calculate the weighted log-rank statistics and their varainces given the weights
wlrcom | A function to calculate the various weighted log-rank statistics and their varainces
wlrutil | A utility function to calculate some common functions in contructing weights