Package: MetaSubtract
Type: Package
Title: Subtracting Summary Statistics of One or more Cohorts from
        Meta-GWAS Results
Version: 1.60
Date: 2020-03-29
Author: Ilja M. Nolte
Maintainer: Ilja M. Nolte <i.m.nolte@umcg.nl>
Description: If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. 
      The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. 
      'MetaSubtract' will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. 
      It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. 
      It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers. 
      See for application: Nolte I.M. et al. (2017); <doi: 10.1038/ejhg.2017.50>.
License: GPL (>= 3)
NeedsCompilation: no
Packaged: 2020-03-29 10:06:42 UTC; NolteIM
Repository: CRAN
Date/Publication: 2020-03-30 12:10:06 UTC
Built: R 4.6.0; ; 2026-04-26 21:58:18 UTC; unix
