Package: MedZIsc
Type: Package
Title: Statistical Framework for Co-Mediators of Zero-Inflated
        Single-Cell Data
Version: 0.0.4
Authors@R: 
    c(person("Seungjun", "Ahn", email = "seungjun.ahn@mountsinai.org",
		 role = c("cre", "aut"),
	    comment = c(ORCID = "0000-0002-4816-8924")),
    person("Zhigang", "Li", email = "zhigang.li@ufl.edu",
		 role = c("ctb")))
Description: A causal mediation framework for single-cell data that incorporates two key features ('MedZIsc', pronounced Magics): (1) zero-inflation using beta regression and (2) overdispersed expression counts using negative binomial regression. This approach also includes a screening step based on penalized and marginal models to handle high-dimensionality. Full methodological details are available in our recent preprint by Ahn S and Li Z (2025) <doi:10.48550/arXiv.2505.22986>.
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.2
Depends: R (>= 3.5.0)
Imports: MASS, betareg, glmnet
Suggests: knitr, rmarkdown, testthat (>= 3.0.0)
LazyData: true
Config/testthat/edition: 3
NeedsCompilation: no
Packaged: 2025-07-12 09:36:32 UTC; seungjunahn
Author: Seungjun Ahn [cre, aut] (ORCID:
    <https://orcid.org/0000-0002-4816-8924>),
  Zhigang Li [ctb]
Maintainer: Seungjun Ahn <seungjun.ahn@mountsinai.org>
Repository: CRAN
Date/Publication: 2025-07-16 15:40:21 UTC
Built: R 4.6.0; ; 2026-04-28 06:32:55 UTC; unix
