---------------------MAMS NEWS-------------------------------------------

MAMS is an R package for designing multi-arm multi stage studies. If you 
are using the package, please cite it as 

Magirr D, Jaki T, Whitehead J (2012) A generalized Dunnett Test for 
Multi-arm Multi-stage Clinical Studies with Treatment Selection. 
Biometrika. 99(2):494-501.

and

Jaki T, Pallmann PS, Magirr D (2019) The R package MAMS for designing 
multi-arm multi-stage clinical trials. Journal of Statistical 
Software. 31(88):4.

Question or suggestions about the package can be sent to

   thomas.jaki@pm.me

--------------------CHANGE LOG--------------------------------------------
Version 3.0.3

  o  Fixed DTL cumulative sample size calculation in summary function
  o  Fixed print output for summary for DTL
  o  Fixed subscript out of bounds error in separate stopping rules for J>K
  o  Changed the way to define the probability of 'T1 being best'
      when 'method = "sep"', now matching the logic of other methods.  

--------------------CHANGE LOG--------------------------------------------
Version 3.0.2

  o  Fixed Cohen's d effect size estimates in the summary() function 
      for "MAMS" objects
  o  Fixed sample size calculation when J=1 and effect sizes were
      specified via 'delta' arguments (i.e., delta, delta0 and sd)

--------------------CHANGE LOG--------------------------------------------
Version 3.0.1

  o  Added handling allocation ratios at the first stage 
      when the control arm is greater than 1 
      (thanks to Peter Greenstreet for the feedback)
  o  Added extra checks for input parameters of allocation ratios
  o  Fixed 'maximum iteration number' computation
  o  Renamed rows and cols in rMat for 'mams' object


--------------------CHANGE LOG--------------------------------------------
Version 3.0.0

  o  Added 2 new designs:
      method = 'separate' for MAMS with a separate stopping rule 
      method = 'dtl' for drop-the-losers design where 
      method = 'simultaneous' (default) corresponds to the MAMS with a 
      simultaneous stopping rule
  o  refined the summary(), print() and plot() functions for "MAMS"
      objects accordingly
  o  updated the C code  to compile with STRICT_R_HEADERS=1 (mandatory for 
      R >= 4.5.0)


--------------------CHANGE LOG--------------------------------------------
Version 2.0.2

  o NA related C code bug fix related to gcc compilers
  o Add documentation for better clarity and user guidance


--------------------CHANGE LOG--------------------------------------------
Version 2.0.1

  o Bug fix when K=1 in mams.sim
  o Add src/init.c file
   
--------------------CHANGE LOG--------------------------------------------
Version 2.0.0

  o Parallelisation framework included for several functions  
  o Recoding of parts of the functions in C
  o Inclusion of new package help file
  o Update of authors
  
--------------------------------------------------------------------------
--------------------------------------------------------------------------
Version 1.4.2

  o Fixed an error in tite.mams
  o Update of author contact information

--------------------------------------------------------------------------

Version 1.4.1

  o Minor bug fix

--------------------------------------------------------------------------
Version 1.4

  o Adjusted code to also provide answers for K=1 and J=1
  o Fixed an error in tite.mams
  o added warning to show that sample size search stopped due to
    maximum reached

--------------------------------------------------------------------------
Version 1.3

  o References updated

--------------------------------------------------------------------------
Version 1.2

  o New function 'ordinal.mams' for ordinal and binary endpoints
  o New function 'tite.mams' for time-to-event endpoints
  o Effect sizes can be specified on traditional or probability scale
  o Search for sample size is capped at a maximum value
  o Harmonised function and input names (most notably, 'step_down_mams' and
    'update_mams' are now called 'stepdown.mams' and 'stepdown.update')
  o Corrected minor bugs in 'mams'
    
--------------------------------------------------------------------------
Version 1.1

  o Corrected minor bug in mams.sim for K=1

--------------------------------------------------------------------------
Version 1.0

  o Altered mams function to improve consistency for different allocation
    ratios

--------------------------------------------------------------------------
Version 0.9

  o Corrected a bug in update_mams

--------------------------------------------------------------------------
Version 0.8

  o Removal of some depreciated code

--------------------------------------------------------------------------
Version 0.7

  o Modified print and summary to only return integer sample sizes
  o Updated mams function to deal with minor inconsistency when J=1

--------------------------------------------------------------------------
Version 0.6

  o Corrected a bug in new.bounds 
  o Corrected a bug in mams.sim
  o A few minor bugs in the plot functions corrected
  o Arguments bty and las for the plot functions added
  o Inconsistencies in the documentation removed

--------------------------------------------------------------------------
Version 0.5

  o A bug in function mams.sim corrected

--------------------------------------------------------------------------
Version 0.4

  o A bug in function mams corrected

--------------------------------------------------------------------------
Version 0.3

  o New function (step_down_mams) to calculate stopping boundaries for all intersection hypothesis tests in a closed testing procedure.
  o New function (update_mams) to update boundaries at an interim analysis to take account of unplanned treatment selection and/or sample size reestimation.
  o Documentation updated

--------------------------------------------------------------------------
Version 0.2

  o New function (mams.sim) to simulate mams studies included
  o New function (new.bounds) to update boundaries based on observed 
    number of observations included
  o Citation information updated
  o Output data.frame of function mams generalized 
  o Additional option to supress sample size calculation included 
    in function mams
  o Documentation updated

--------------------------------------------------------------------------
Version 0.1

  o Initial release

--------------------------------------------------------------------------

