Package: ISPYARDSWinProbabilityGSDesign
Type: Package
Title: Trial Design in Respiratory Disease Based on the Win Probability
Version: 0.1.0
Authors@R: c(person("Andrew G", "Chapple", role = c("aut","cre"),
                     email="a.chapple@qlhc.org"),
                     person("Andrew", "Chapple", role = c("ctb"),
                      email = "andrewchapple21@gmail.com"),
                      person("Peter", "Norwood", role = c("ctb"),
                      email = "p.norwood@qlhc.org"),
                      person("Martin", "Eklund", role = c("ctb"),
                      email = "martin.eklund@ki.se"),
                       person("Derek", "Russell", role = c("ctb"),
                      email = "dwrussell@uabmc.edu"),
                             person("Phil", "Beineke", role = c("ctb"),
                      email = "p.beineke@qlhc.org"),
                      person("Quantum Leap Healthcare Collaborative", role=c("ctb","cph"))
                      )
Description: Provides analysis results and trial simulation functions for the I-SPY Acute Respiratory Disease Syndrome trial based on composite ranked outcomes. The composite ranked outcome is a hierarchical outcome where trial participants are ranked first by 28 day mortality, then ventilator days, then by advanced respiratory support days. A Bayesian win probability approach is used for analysis. Trial design options include group sequential looks for safety, superiority, futility, and adjustment of randomization probabilities. 
License: GPL-2
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2
Imports: DFBA
NeedsCompilation: no
Packaged: 2025-09-10 21:05:33 UTC; a.chapple
Author: Andrew G Chapple [aut, cre],
  Andrew Chapple [ctb],
  Peter Norwood [ctb],
  Martin Eklund [ctb],
  Derek Russell [ctb],
  Phil Beineke [ctb],
  Quantum Leap Healthcare Collaborative [ctb, cph]
Maintainer: Andrew G Chapple <a.chapple@qlhc.org>
Depends: R (>= 3.5.0)
Repository: CRAN
Date/Publication: 2025-09-15 09:10:25 UTC
Built: R 4.6.0; ; 2026-04-26 20:30:12 UTC; unix
