Package: HybridDesign
Type: Package
Title: Hybrid Design for Phase I Dose-Finding Studies
Version: 1.0
Authors@R: 
    c(person(given = "Heng",
           family = "Zhou",
           role = c("aut", "cre"),
           email = "heng.zhou@merck.com"),
    person(given = "Feng",
           family = "Zhou",
           role = "aut"),
    person(given = "Jason",
           family = "Liao",
           role = "aut"))
Maintainer: Heng Zhou <heng.zhou@merck.com>
Description: The Hybrid design is a combination of model-assisted design (e.g., the modified 
             Toxicity Probability Interval design) with dose-toxicity model-based design for 
             phase I dose-finding studies. The hybrid design controls the overdosing 
             toxicity well and leads to a recommended dose closer to the true maximum tolerated 
             dose (MTD) due to its ability to calibrate for an intermediate dose. More details 
             can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Imports: testit, ResourceSelection
Depends: R (>= 3.6)
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.1.2
NeedsCompilation: no
Packaged: 2022-12-14 19:42:26 UTC; zhouheng
Author: Heng Zhou [aut, cre],
  Feng Zhou [aut],
  Jason Liao [aut]
Repository: CRAN
Date/Publication: 2022-12-15 09:10:02 UTC
Built: R 4.6.0; ; 2026-04-27 17:33:33 UTC; unix
