Package: GSSE
Type: Package
Title: Genotype-Specific Survival Estimation
Description: We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees.  We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function.  The estimators are calculated via an expectation-maximization algorithm.
Version: 0.1
Date: 2015-10-17
Author: Baosheng Liang, Yuanjia Wang and Donglin Zeng
Maintainer: Baosheng Liang <liangbsunc@gmail.com>
Depends: R(>= 3.0.1)
Suggests: MASS
Imports: Iso (>= 0.0-17), splines, stats, zoo (>= 1.7-12)
License: GPL (>= 2)
LazyLoad: yes
NeedsCompilation: no
Packaged: 2015-10-20 01:00:51 UTC; BLiang
Repository: CRAN
Date/Publication: 2015-10-20 08:06:35
Built: R 4.6.0; ; 2026-04-27 09:55:00 UTC; unix
