R: Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes

# Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes

## Documentation for package ‘DTEBOP2’ version 1.0.3

- DESCRIPTION file
- User guides, package vignettes and other documentation

## Help Pages

conduct | Computes the hazard ratio between post- and pre-separation periods, provides the 95% Bayesian credible interval, and makes a Go/No-Go decision based on the trial data. This function is intended for interim and final analyses in two-arm survival trials with delayed treatment effects.
event_fun | Return expected event number at interim analysis and final analysis.
Experimental | Nivolumab KM data used for reconstructing PFS KM curve
generate_pe | Generate event times from a piecewise exponential distribution.
get.optimal_2arm_piecewise | Obtain Optimal Design Parameters for DTE-BOP2 Design
getoc_2arm_piecewise | Compute Operating Characteristics for Two-Arm Piecewise Exponential Designs
rtrunc_gamma | Generate Random Variables from a Truncated Gamma Distribution.
SOC | Docetaxel KM data used for reconstructing PFS KM curve
trunc_gamma_para | Estimate Shape and Scale Parameters for Truncated Gamma Distribution
TTOT_fun | Compute the Total Time-on-Test (TTOT) Statistic
Two_stage_sample_size | Calculate Sample Sizes for a Two-Stage Trial Design.