Package: ClusTCR2
Title: Identifying Similar T Cell Receptor Hyper-Variable Sequences
        with 'ClusTCR2'
Version: 1.7.3.01
Date: 2024-05-15
Authors@R: c(person("Kerry A.", "Mullan", role = c("aut","cre"),
                     email = "Kerry.Mullan@uantwerpen.be"),
              person("Sebastiaan", "Valkiers", role = c("aut","ctb")),
              person("Kris", "Laukens", role = c("aut","ctb")),
              person("Pieter", "Meysman", role = c("aut","ctb"),
                     email = ""))
Author: Kerry A. Mullan [aut, cre],
  Sebastiaan Valkiers [aut, ctb],
  Kris Laukens [aut, ctb],
  Pieter Meysman [aut, ctb]
Description: Enhancing T cell receptor (TCR) sequence analysis, 'ClusTCR2', based on 'ClusTCR' python program, leverages Hamming distance to compare the complement-determining region three (CDR3) sequences for sequence similarity, variable gene (V gene) and length. The second step employs the Markov Cluster Algorithm to identify clusters within an undirected graph, providing a summary of amino acid motifs and matrix for generating network plots. Tailored for single-cell RNA-seq data with integrated TCR-seq information, 'ClusTCR2' is integrated into the Single Cell TCR and Expression Grouped Ontologies (STEGO) R application or 'STEGO.R'. See the two publications for more details. Sebastiaan Valkiers, Max Van Houcke, Kris Laukens, Pieter Meysman (2021) <doi:10.1093/bioinformatics/btab446>, Kerry A. Mullan, My Ha, Sebastiaan Valkiers, Nicky de Vrij, Benson Ogunjimi, Kris Laukens, Pieter Meysman (2023) <doi:10.1101/2023.09.27.559702>.
Maintainer: Kerry A. Mullan <Kerry.Mullan@uantwerpen.be>
License: GPL (>= 3)
Encoding: UTF-8
RoxygenNote: 7.3.1
Suggests: knitr, rmarkdown, testthat (>= 3.0.0)
Config/testthat/edition: 3
Imports: DescTools, ggplot2, ggseqlogo, network, plyr, RColorBrewer,
        stringr, scales, sna, VLF
biocViews: GeneTarget, SingleCell
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2024-05-15 16:22:16 UTC; kerrymullan
Repository: CRAN
Date/Publication: 2024-05-16 15:00:19 UTC
Built: R 4.6.0; ; 2026-04-30 09:08:16 UTC; unix
