Package: BElikelihood
Type: Package
Title: Likelihood Method for Evaluating Bioequivalence
Version: 1.1
Date: 2024-02-29
Maintainer: Liping Du <liping.du@vumc.org>
Authors@R: 
    c(person("Liping", "Du", role = c("aut", "cre"),
             email = "liping.du@vumc.org",
             comment=c(ORCID = "0000-0003-4926-2135")),
    person("Leena", "Choi", role = "aut",
           email = "naturechoi@gmail.com",
           comment = c(ORCID = "0000-0002-2544-7090")),
    person("Cole", "Beck", role = "aut",
           email = "cole.beck@vumc.org",
           comment = c(ORCID = "0000-0002-6849-6255")))
Description: A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.
License: GPL (>= 3)
Imports: ggplot2, mvtnorm
Suggests: knitr, nlme, rmarkdown
RoxygenNote: 7.3.1
Depends: R (>= 3.5.0)
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2024-03-01 00:46:33 UTC; beckca
Author: Liping Du [aut, cre] (<https://orcid.org/0000-0003-4926-2135>),
  Leena Choi [aut] (<https://orcid.org/0000-0002-2544-7090>),
  Cole Beck [aut] (<https://orcid.org/0000-0002-6849-6255>)
Repository: CRAN
Date/Publication: 2024-03-05 10:30:05 UTC
Built: R 4.6.0; ; 2026-04-27 23:24:31 UTC; unix
