Type: Package
Package: disprofas
Title: Non-Parametric Dissolution Profile Analysis
Version: 0.2.1
Authors@R: c(
    person("Pius", "Dahinden", , "pius.dahinden@tillotts.com", role = c("aut", "cre")),
    person("Tillotts Pharma AG", , , "tillotts@tillotts.com", role = c("cph", "fnd"))
  )
Description: Similarity of dissolution profiles is assessed using the
    similarity factor f2 according to the EMA guideline (European
    Medicines Agency 2010) "On the investigation of bioequivalence".
    Dissolution profiles are regarded as similar if the f2 value is
    between 50 and 100. For the applicability of the similarity factor f2,
    the variability between profiles needs to be within certain limits.
    Often, this constraint is violated. One possibility in this situation
    is to resample the measured profiles in order to obtain a bootstrap
    estimate of f2 (Shah et al. (1998) <doi:10.1023/A:1011976615750>).
    Other alternatives are the model-independent non-parametric
    multivariate confidence region (MCR) procedure (Tsong et al. (1996)
    <doi:10.1177/009286159603000427>) or the T2-test for equivalence
    procedure (Hoffelder (2016)
    <https://www.ecv.de/suse_item.php?suseId=Z|pi|8430>). Functions for
    estimation of f1, f2, bootstrap f2, MCR / T2-test for equivalence
    procedure are implemented.
License: GPL (>= 2)
URL: https://github.com/piusdahinden/disprofas
BugReports: https://github.com/piusdahinden/disprofas/issues
Depends: R (>= 4.0)
Imports: boot, ggplot2, rlang
Suggests: testthat, T2EQ
Encoding: UTF-8
Language: en-GB
LazyData: true
RoxygenNote: 7.3.2
NeedsCompilation: no
Packaged: 2025-03-23 13:54:12 UTC; piusd
Author: Pius Dahinden [aut, cre],
  Tillotts Pharma AG [cph, fnd]
Maintainer: Pius Dahinden <pius.dahinden@tillotts.com>
Repository: CRAN
Date/Publication: 2025-03-24 01:00:07 UTC
Built: R 4.3.3; ; 2025-03-24 03:17:27 UTC; unix
