Type: Package
Package: nlmixr2autoinit
Title: Automatic Generation of Initial Estimates for Population
        Pharmacokinetic Modeling
Version: 1.0.1
Authors@R: c(person("Zhonghui","Huang", role = c("aut", "cre"), email = "huangzhonghui22@gmail.com"),
   person("Joseph", "Standing", role = "ctb", email = "j.standing@ucl.ac.uk"),
   person("Matthew", "Fidler", role = "ctb", email = "matthew.fidler@gmail.com"),
   person("Frank", "Kloprogge", role = "ctb", email = "f.kloprogge@ucl.ac.uk"))
Description: Provides automated methods for generating initial parameter estimates 
    in population pharmacokinetic modeling. The pipeline integrates adaptive single-point 
    methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter 
    sweeping across pharmacokinetic models. It estimates residual unexplained variability 
    using either data-driven or fixed-fraction approaches and assigns pragmatic initial values 
    for inter-individual variability. These strategies are designed to improve model 
    robustness and convergence in 'nlmixr2' workflows. For more details see 
    Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) 
    <doi:10.1007/s10928-025-10000-z>.
License: GPL (>= 3)
URL: https://ucl-pharmacometrics.github.io/nlmixr2autoinit/,
        https://github.com/ucl-pharmacometrics/nlmixr2autoinit
BugReports: https://github.com/ucl-pharmacometrics/nlmixr2autoinit/issues
Depends: nlmixr2data, R (>= 4.0)
Imports: nlmixr2, nlmixr2est, rxode2, dplyr, tidyr, crayon, purrr,
        knitr, magrittr, progressr, tibble, vpc
Encoding: UTF-8
Language: en-US
NeedsCompilation: no
Config/roxygen2/version: 8.0.0
Packaged: 2026-06-08 18:37:55 UTC; huang
Author: Zhonghui Huang [aut, cre],
  Joseph Standing [ctb],
  Matthew Fidler [ctb],
  Frank Kloprogge [ctb]
Maintainer: Zhonghui Huang <huangzhonghui22@gmail.com>
Repository: CRAN
Date/Publication: 2026-06-08 20:10:11 UTC
Built: R 4.5.2; ; 2026-06-08 22:04:40 UTC; unix
