Package: mectx
Type: Package
Title: MEchanistic Clustering - Treatment eXposure Framework
Version: 1.1.1
Authors@R: 
    c(person(given = "Dipankor",
             family = "Dhrubo",
             email = "dhrubo.2@osu.edu",
             role = c("aut", "cre")),
      person(given = "Daniel",
             family = "Spakowicz",
             role = c("aut"),
             email = "daniel.spakowicz@osumc.edu",
             comment = c(ORCID = "0000-0003-2314-6435")))
Description: Implements the MEC-TX (MEchanistic Clustering - Treatment
    eXposure) framework for encoding, clustering, and survival analysis of
    real-world oncology treatment timelines. Provides functions for
    normalising medication records, computing treatment intervals, performing
    k-means clustering in PCA space, assigning line-of-therapy labels, and
    comparing survival outcomes across treatment groups. Designed for use
    with registry-based cohorts such as the ORIEN AVATAR dataset. Methods
    follow the digital-twin framework described in Dhrubo and Spakowicz (2026)
    <https://github.com/spakowiczlab/mec-tx>.
    treatment timelines using the MEC-TX digital-twin framework.
License: MIT + file LICENSE
Encoding: UTF-8
Language: en-US
RoxygenNote: 7.3.3
Depends: R (>= 4.4.0)
Imports: magrittr, broom, dplyr, forcats, ggnewscale, ggplot2,
        patchwork, purrr, stats, stringr, survival, tibble, tidyr, umap
Suggests: testthat (>= 3.0.0), devtools, roxygen2
Config/testthat/edition: 3
Date: 2026-04-27
NeedsCompilation: no
Packaged: 2026-05-05 19:59:19 UTC; dipankor99
Author: Dipankor Dhrubo [aut, cre],
  Daniel Spakowicz [aut] (ORCID: <https://orcid.org/0000-0003-2314-6435>)
Maintainer: Dipankor Dhrubo <dhrubo.2@osu.edu>
Repository: CRAN
Date/Publication: 2026-05-11 18:40:08 UTC
Built: R 4.5.2; ; 2026-05-11 20:20:08 UTC; unix
