Package: bfboinet
Type: Package
Title: Backfill Bayesian Optimal Interval Design Using Efficacy and
        Toxicity
Version: 1.1.0
Authors@R: c(
    person("Jing", "Zhu", email = "zhujing716@gmail.com", role = c("cre","aut")),
    person("Kentaro", "Takeda", email = "kentaro.takeda.statistics@gmail.com", role = "aut"),
    person("Belay Birlie", "Yimer", role = "aut"))
Description: Implements the Backfill Bayesian Optimal Interval Design (BF-BOIN-ET), 
             a novel clinical trial methodology for dose optimization that simultaneously consider both efficacy 
             and toxicity outcome as described in (Takeda et al  (2025) <doi:10.1002/pst.2470>).
             The package has been extended to include a seamless two-stage phase I/II trial design with backfill 
             and joint efficacy and toxicity monitoring as described in (Takeda et al (2026) <doi:10.1002/pst.70092>).
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.3
Imports: Iso, copula, dplyr, tidyselect, magrittr, BOP2FE, boinet, BOIN
NeedsCompilation: no
Packaged: 2026-04-29 05:56:47 UTC; A4021579
Author: Jing Zhu [cre, aut],
  Kentaro Takeda [aut],
  Belay Birlie Yimer [aut]
Maintainer: Jing Zhu <zhujing716@gmail.com>
Repository: CRAN
Date/Publication: 2026-04-29 06:20:02 UTC
Built: R 4.5.2; ; 2026-04-29 10:50:03 UTC; unix
