Package: cwot
Type: Package
Title: Cauchy Weighted Joint Test for Pharmacogenetics Analysis
Version: 0.1.0
Authors@R: c(
    person(given="Hong", family="Zhang", 
    email="hzhang@wpi.edu", role = c("aut", "cre"),
    comment=c(ORCID = "0000-0002-8869-8671"))
  )
Description: A flexible and robust joint test of the single nucleotide polymorphism (SNP) main effect and genotype-by-treatment interaction effect for continuous and binary endpoints. Two analytic procedures, Cauchy weighted joint test (CWOT) and adaptively weighted joint test (AWOT), are proposed to accurately calculate the joint test p-value. The proposed methods are evaluated through extensive simulations under various scenarios. The results show that the proposed AWOT and CWOT control type I error well and outperform existing methods in detecting the most interesting signal patterns in pharmacogenetics (PGx) association studies. For reference, see Hong Zhang, Devan Mehrotra and Judong Shen (2022) <doi:10.13140/RG.2.2.28323.53280>.
License: GPL-2
Imports: stats, SPAtest, mvtnorm
Encoding: UTF-8
RoxygenNote: 7.1.1
NeedsCompilation: no
Packaged: 2022-09-22 18:54:08 UTC; consi
Author: Hong Zhang [aut, cre] (<https://orcid.org/0000-0002-8869-8671>)
Maintainer: Hong Zhang <hzhang@wpi.edu>
Repository: CRAN
Date/Publication: 2022-09-23 14:40:02 UTC
Built: R 4.3.3; ; 2025-01-24 06:19:40 UTC; unix
