Package: boinet
Version: 1.0.0
Title: Conduct Simulation Study of Bayesian Optimal Interval Design
        with BOIN-ET Family
Authors@R: c(
    person(given  = "Yusuke",
           family = "Yamaguchi",
           role   = c("aut","cre"),
           email  = "yamagubed@gmail.com"),
    person(given  = "Kentaro",
           family = "Takeda",
           role   = c("aut")))
Description: Bayesian optimal interval based on both efficacy and toxicity outcomes (BOIN-ET) design is a model-assisted oncology phase I/II trial design, aiming to establish an optimal biological dose accounting for efficacy and toxicity in the framework of dose-finding. Some extensions of BOIN-ET design are also available to allow for time-to-event efficacy and toxicity outcomes based on cumulative and pending data (time-to-event BOIN-ET: TITE-BOIN-ET), ordinal graded efficacy and toxicity outcomes (generalized BOIN-ET: gBOIN-ET), and their combination (TITE-gBOIN-ET). 'boinet' is a package to implement the BOIN-ET design family and supports the conduct of simulation studies to assess operating characteristics of BOIN-ET, TITE-BOIN-ET, gBOIN-ET, and TITE-gBOIN-ET, where users can choose design parameters in flexible and straightforward ways depending on their own application.
License: MIT + file LICENSE
Encoding: UTF-8
RoxygenNote: 7.2.3
Imports: Iso, mfp, copula
Suggests: testthat (>= 3.0.0)
Config/testthat/edition: 3
NeedsCompilation: no
Packaged: 2023-06-08 22:53:03 UTC; API18340
Author: Yusuke Yamaguchi [aut, cre],
  Kentaro Takeda [aut]
Maintainer: Yusuke Yamaguchi <yamagubed@gmail.com>
Repository: CRAN
Date/Publication: 2023-06-08 23:12:53 UTC
Built: R 4.2.0; ; 2023-07-11 00:43:10 UTC; unix
