>CHEK2_Hsap_NP_009125.1
M-S-RESD--VEAQ-QSHGSSACSQPHG------------SVT-------
---QSQ-GSSSQSQGI------SSSSTSTMPNSSQSSHSSSGTLSSLETV
STQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVN--DNYW
FGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHS
G-NGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYP
KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE
A-DPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFD
KVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEED
CLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS-VGTA-GYNRAVD
CWSLGVILFICLSGYPPFSE-----HRTQ--VSLKDQITSGKYNFIPEVW
AEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEE
NEST-----------------------------------ALPQVLAQPST
SRKRPR-EGEAEGAETTKRPAVCAAVL
>CHEK2_Mmus_NP_057890
MKSHHQSH--SSTSSKAHDSASCSQSQG------------GFS-------
---QPQ-GTPSQLHELSQYQGSSSSSTGTVPSSSQSSHSSSGTLSSLETV
STQELCSIPEDQEPE-----EPGPAPWARLWALQDGFSNLDCVN--DNYW
FGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHS
G-NGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYP
KELRDEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSRE
A-DTAPSVETEIEILKKLNHPCIIKIKDVFDAED-YYIVLELMEGGELFD
RVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEED
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVS-NGTA-GYSRAVD
CWSLGVILFICLSGYPPFSE-----HKTQ--VSLKDQITSGKYNFIPEVW
TDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQE
KNSV-----------------------------------TLPVAPAQTS-
SQKRPL-ELEVEGMPSTKRLSVCGAVL
>CHEK2_Cfam_a
M-S-RETD--VECQ-QSHGSGACSQSQG------------TFS-------
---QSQ-GISSQTHGSSSHSQGTSSSTSTAPTSSQSSHSSSGTLSSLDTV
STQELCSIPEDQEPE-----EPVPAPWARLWALQDGFPNLECVN--DNYW
FGRDRSCEYCFDEPLLKRTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS
G-NGTFVNRELVGKGRRLPLNNNSEIALSVWSNKVFVFFDLTVDDQSVYP
KELRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSERE
A-DPALDVETEIEILKKLNHPCIIKIKDFFDAED-YYIVLELMEGGELFD
RVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQKED
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS-FGTA-GYNRAVD
CWSLGVILFICLSGYPPFSE-----HKTQ--VPLKDQITSGKFNFIPEVW
AEVSEKALDLVKKLLMVDPKVRFTTEEALRHPWLQDEDMKRKFQNLLSEE
KKST-----------------------------------ALLQVPAQPST
SRKRLL-EGEAEDADTTKRLAMCAAVS
>CHEK2_Btau_AAX46445
M-S-RETN--VERQ-QPRGSAS-PQSQG------------GFS-------
---QSQ-GPSSQPHSS------SSQSQGT---SSQSSHSSSGTLSSLDTV
STQELYSIPEDQEPE-----EPVPAPWARLWALQDGFSNLDCIN--DSYW
FGRDRNCEYCFDEPLLKSTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS
G-NGTFVNRELVGKGRRLPLSNNSEIALSVWSNKVFVFFDLTVDDQSVYP
KELRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSERE
A-DPALDVETEIEILKKLNHPCIIKIKDFFDAED-YYIVLELMEGGELFD
RVVGHKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSPKED
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS-FGTA-GYNRAVD
CWSLGVILFICLSGYPPFSE-----HKTQ--VSLKDQITSGKYNFIPEVW
AEVSEKALDLVKKLLIVDPKARFTTEEALRHPWLQDEDMKRKFNNLLSEE
DKLM-----------------------------------AVTQVPAQPST
SRKRLL-EGEAESADPTKRLAVCAAVS
>Lafr_CHEK2_Pred_v1_1
M-S-READ--MDCQ-QSQDGTS-SQSQGATSSQSATSSQPAFSSSWQSHS
SSLQSP-GLSSQPHGSSQSQNTSGSSSGTVHTSSQSSHSSSGTLSSVDTV
STQELYSIPEDQEPE-----EPIPAPWARLWALQDGFSNLECVN--DNYW
FGRDRSCEYCFDEPLLKRTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS
G-NGTFVNRELVGKGRRLPLNNNCEIALSVWNNKVFVFFDLTVDDQSVYP
KELRDQYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE
A-DPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFD
RVVGNRRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQKED
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVS-FGTA-GYNRAVD
CWSLGVILFICLSGYPPFSE-----HKTQ--VSLKDQITSGKYNFIPEVW
AEVSEKALDLVKKLLVVDPKERFTTEDALRHPWLQDEDMKRKFEDLLLEE
NKST-----------------------------------PVPQVPTQPST
SRKRPL-EGEVEDTDTPKRLAVCAAVS
>CHEK2_Mdom_cDNA_V1
M-S-RETG--GDSQ-QS---------------------------------
---QS----TSQSQNA------SSSSSGA--SHSQSSHSSSGTISSLDTV
PTQDLPSIPEDEEPE-----ELDPQPWGRLWALDDGFSNLDCVE--NDYW
FGRDRRCEYSFDKPGLKKTDKYRTYSKKHFRIFREKGPKNSYIAYIEDHS
G-NGTFVNRELVGKEKRLPLSNNCEIALSVPTNKVFVFFDLTVDDQSIYP
SELREKYIMSKTLGSGACGEVKLAFERKTCKKVAVKIISKRKFSICATRE
A-DPAFNVETEIEILKKLNHPCIIKIKNFFDAED-YFIVLELMEGGELFE
RVVGNKRLNEATCKLYFYQMLLAVKYLHENGIIHRDLKPENVLLSSQQED
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVVLS-MGSA-GYTRAVD
CWSLGVILFVCLSGYPPFSE-----HKTQ--VPLKDQIISGKYKLIPEVW
KAVSDTALDLVKKLLVVDPKKRYTTEEALAHPWLQDEEMKSKFHALLMEE
TMPP-----------------------------------HLPPPPAQLST
SRKRPH-EGEEEDEASSSGHCLASTSLSTTQLPEKRERK
>CHEK2_Oana_pep_v1
M-S-RESR--GESQ-QS---------------------------------
---QS----ASQSQNA------SSSSSSATHTSSQSSYSSSGTLSSLDTI
PTQDLPSIPEDQEPE-----EPAPAAWGQLWALQDGFSNLECVL--DDYW
FGRDKSCDYSFDKPELNRTEKYKTYSKKHFRIFRELGPKSSYITYIEDHS
G-NGTFVNKECVGKGKRLVLSNNSEIALSLLTNKVFVFFDLTVDDQSIYP
SEFREKYIMYKTLGSGACGEVKLAFEKTTCKKVAVKIISKRKFSFCSVRE
A-DPAQSVETEIEILKKLNHPCIVKIKNFFEAED-YFIVLELMEGGELFD
RVARKGGLKEATCKLYFYQMLLAVKYLHDNGIIHRDLKPENVLLSSHEEN
CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS-FGTA-GYKSSVD
CWSLGVILFVCLGGYPPFAEPSIAKHKTQ--VPLKDQITSGTLNFIPKAW
AHVSEMAVDLVKKLLVVDPNERLTTEKALEHPWLQDESMKNTFERLLMQQ
KESI-----------------------------------ALPQHPIQPST
SRKRAW-EEEEEQPGTSKCS-VPCASFQTIQVLEKRQRK
>CHEK2_Ggal_pep1
M-S-RETR--SDAQ-PS---------------------------------
---QG----TQPSQGG------TSSSSSASQGASQSS-SSSGTLSSLDTV
PTQELPSIPEDPEPD-----ELVPQPWGRLFALGKGFSNWDCVN--DEYW
FGRDKSCDYSFSKLGLSETGFYQNYSKKHFRIFREMGPKNSYVAYIEDHS
A-NGTFINRELIGKGKRLPLTHNSEIALSIQTNKVFVFSDLTVDDQLVFP
REFREKYIMSKTLGSGACGEVKLAFEKSTCNKVAVKIINKRKFMASGGRE
A-NPAFNINTEIEILKKIDHPCLIKIKNFFEAED-YYIVLELMEGGELYD
RVSRPVKMKEATCKLYFYQMLLAVKYLHDNGIIHRDLKPENVLLSSSEET
CLIKITDFGQSKILGETSLMKTLCGTPTYLAPEVLNS-FGTA-GYSRAVD
CWSLGVILFVCLCGYPPFNE-----QNTQ--LSLKDQITRGEYTFISKEW
KHVSNMALDLVKKLLVVDPSKRFTIEEALEHPWLQDEDMKNTFQQLLAQT
SATM-----------------------------------NPPQTSKMPVA
TRKRLH-ENEDE-SVSSKRD-VPSTSLQKMR
>CHEK2_Xlav_AF326574_1
MMS-RDTK--TESQ-Q----------------------------------
------------SQGT-----SSSSSSSAPQSYSQSS-S-SGTLSSLDTV
PVQDLASIPEDPEID-----EDIPQPWGRLWALGKGFLNHDCLH--EEYV
FGRDKKCDYTFDIPVLNQTDRYKTYSKRHFRIFQELGHGHSRVAYIEDLS
G-NGTFVNKEIIGKGRTLPLTNNAEIALSLPTNKVFVFSDLSVDDQTIYP
KDFIDKYIMSRPIGSGACGEVKLAFQKSVCKKVAVKIISKRKFKMNTSSN
E-HP-ISVDTEIEILKKLDHPCIIKIENFFDSEDFYYIVLELMEGGELFD
RVVNSTRLREPIAKLYFYQMLLAVQYLHENGVIHRDLKPENVLLSSTSEE
CCIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNT-AGTT-GYSSAVD
CWSLGVILFVCLCGYPPFSE-----QNSN--IPLKNQIAEGKYTYIAAAW
RNVSEQAFDLVKNLLVVDPEQRLTTKQALEHPWLQDDSMKHTVERLMYGV
DHTM-----------------------------------PPP---IKKNI
IRKRGH-EWDQDASTSSCSEILPTSA-------EKRAKR
>CHEK2_Drer_NP_956339.1
M-S-EEAGPSGESQ-S----------------------------------
---QTQ--SQTQSQPA-------SSSSSAPTSSSQGSSSGSGTLSSVDTV
PVQELQSIPEDEE-------EVQPQVWGRTIPLKQGFSVLNCTE--NQYS
FGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRD-----ENLVYLEDLS
G-NGTWVDDEKLGNGKQSLLGNNSVIALAEQKHQVFMFIDKMADDQANLP
LEFSKKYHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHDFP----SI
G-TATRNAEREIEILKKIDHPCLIKTEDFYQTEDSYYIVLEYIEGGELFG
RIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHDDI
CLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTH-ASTV-GYTKAVD
YWSLGVLLFICLGGYPPFNT-----ECTT--MSVREQIINGEYRFIPSQW
KNVSNEAKDLVKKLLVVDPQKRLSVEEALEHPWLKDDRMRQNANQLMNPG
AANQ-----------------------------------PMRPEA-----
TRKRKAQEGEGEP--SSKRKPGP
>Spur_CHEK2_cDNA.seq_1
M-Y-ESDM--STAS-AG---------------------------------
-----------GSASS-------SSIEPNSTSSASASLSSAGTLSSMETI
PTQEVAEGDFDFA-------EERVVVWGRLYPVGKCFSSIDFLDTKDEYI
FGRDPSCDVCYNGPEISKNPCYQTLSKTHFRIFKE-SNDNCNFYFIEDKS
S-NGTFVNGEKIGKGKKQVLNNNDEIALSLSKNKAYVFMDTKDSDQSNLP
EALREKFIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMV
R-NMEKTVMEEVRILKRLHHPCIIGIEDVCDTPEVLYIVLELVESGELFD
RVVSLGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKE
TILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTS-MGMG-GYTKAVD
CWSIGVILYICLAGYPPFSD-----EIKA--MNLDEQIKRGYYSFPTKYW
GSVSAPAIDMVKKLLTVDPKRRLTTKQALAHPWLQDQEVIDKAEKVMYPN
RNGQ-----------------------------------MLP--PSAPVR
SYYS-HF------------MW
>CHEK2_Cint_AK112349
M-E-DTND--ERPK-EKNASSSV---------------------------
---ESDKEKMRSPASL-------PASQEKVSSSSGTGTSSGNTVSSADTV
PTQEITDSQGVEL-------EP---VWGVLHSMQPEFYSLNLRD--EQYT
FGRANSCDYCFDIKTIKSTSRYKHYSKRHFAIRRVKLEDETYQVFIEDFG
GQNGVYVNGVKIPSGRKQTIKTSDEIGIAYNNFNVFLFIDKEKDSDLEVS
DEFSKKYITHKLLGKGACGQVWEVWERFCAGKFAVKIISKTYLSVS----
--PSSKDVIKEADILRKLSHPCIIGVHDVVDLPQNLYIVLEFAKGGELFK
RLERGGKLPEKIAKLYFFQMLSAVKYLHDNEITHRDLKPENILLMSTEEP
CLIKITDFGMSRLVEEKSLMKTLAGTPSYLAPEIIKQHMGLGKGYTKQVD
LWSLGVILYVCLVAFPPFSA-----ELTETGQSIDEQILSANYSFQNQPW
STVSNDAKNLVSSLLVLNANDRLTTSAAVAHPWLQDSEMIRTANSLMSTV
EIKPYQEFMGSHSASFDTRKISTDNDDSASDSSRPASLEMLPQTINLPSS
AEKRCHTPNSSAEEPTAKLSKC
>Dmel
M-A-RDTQ--G---------------------------------------
---------------------------------------TQGTQSQASNI
WTQ-V-ESQPME-----------KIVWGRLYGKNIKIKSLDLNN--DEFT
AGRGEANDLILTLNDLPEKILTR-ISKVHFIIKRANCELTNPV-YIQDLS
R-NGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLP
EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPST
NFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLN
RIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEE
TLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLIT-GGRE-AYTKKVD
IWSLGVVLFTCLSGTLPFSD-----EYGT--PAA-QQIKKGRFAYGHPSW
KSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLD
GMEI----------------------------------------------
-------EEENFLEPPTKRSRR

