# CodelistGenerator options: examples with a with mock vocabulary

## Mock vocabulary database

Let´s say we have a mock vocabulary database with these hypothetical concepts and relationships.

## Search for exact keyword match

To find “Musculoskeletal disorder” we can search for that like so

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "Musculoskeletal disorder",
      domains = "Condition",
      includeDescendants = FALSE,
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> ✔ 1 candidate concept identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 1
    #> Columns: 6
    #> $ concept_id       <int> 1
    #> $ found_from       <chr> "From initial search"
    #> $ concept_name     <chr> "Musculoskeletal disorder"
    #> $ domain_id        <chr> "Condition"
    #> $ vocabulary_id    <chr> "SNOMED"
    #> $ standard_concept <chr> "standard"

Note, we would also identify it based on a partial match

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "Musculoskeletal",
      domains = "Condition",
      includeDescendants = FALSE
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> ✔ 1 candidate concept identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 1
    #> Columns: 6
    #> $ concept_id       <int> 1
    #> $ found_from       <chr> "From initial search"
    #> $ concept_name     <chr> "Musculoskeletal disorder"
    #> $ domain_id        <chr> "Condition"
    #> $ vocabulary_id    <chr> "SNOMED"
    #> $ standard_concept <chr> "standard"

## Add descendants

To include descendants of an identified code, we can set includeDescendants to TRUE

    getCandidateCodes(
      cdm = cdm,
      keywords = "Musculoskeletal disorder",
      domains = "Condition",
      includeDescendants = TRUE
    ) %>%
      glimpse()
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> ✔ 5 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds
    #> Rows: 5
    #> Columns: 6
    #> $ concept_id       <int> 1, 2, 3, 4, 5
    #> $ found_from       <chr> "From initial search", "From descendants", "From desc…
    #> $ concept_name     <chr> "Musculoskeletal disorder", "Osteoarthrosis", "Arthri…
    #> $ domain_id        <chr> "Condition", "Condition", "Condition", "Condition", "…
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED", "SNOMED", "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard", "standard", "standard", "stan…

## Multiple search terms

We can also search for multiple keywords at the same time, and would have picked these all up with the following search

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = c(
        "Musculoskeletal disorder",
        "arthritis",
        "arthrosis"
      ),
      domains = "Condition",
      includeDescendants = FALSE
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> ✔ 5 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 5
    #> Columns: 6
    #> $ concept_id       <int> 1, 3, 4, 5, 2
    #> $ found_from       <chr> "From initial search", "From initial search", "From i…
    #> $ concept_name     <chr> "Musculoskeletal disorder", "Arthritis", "Osteoarthri…
    #> $ domain_id        <chr> "Condition", "Condition", "Condition", "Condition", "…
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED", "SNOMED", "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard", "standard", "standard", "stan…

## Add ancestor

To include the ancestors one level above the identified concepts we can set includeAncestor to TRUE

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "Osteoarthritis of knee",
      includeAncestor = TRUE,
      domains = "Condition"
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> condition domain: Adding ancestor
    #> ✔ 2 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 2
    #> Columns: 6
    #> $ concept_id       <int> 4, 3
    #> $ found_from       <chr> "From initial search", "From ancestor"
    #> $ concept_name     <chr> "Osteoarthritis of knee", "Arthritis"
    #> $ domain_id        <chr> "Condition", "Condition"
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard"

## Searches with multiple words

We can also find concepts with multiple words even if they are in a different order. For example, a search for “Knee osteoarthritis” will pick up “Osteoarthritis of knee”.

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "Knee osteoarthritis",
      domains = "Condition",
      includeDescendants = TRUE
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> ✔ 1 candidate concept identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 1
    #> Columns: 6
    #> $ concept_id       <int> 4
    #> $ found_from       <chr> "From initial search"
    #> $ concept_name     <chr> "Osteoarthritis of knee"
    #> $ domain_id        <chr> "Condition"
    #> $ vocabulary_id    <chr> "SNOMED"
    #> $ standard_concept <chr> "standard"

## With exclusions

We can also exclude specific terms

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "arthritis",
      exclude = "Hip osteoarthritis",
      domains = "Condition"
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> ✔ 2 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 2
    #> Columns: 6
    #> $ concept_id       <int> 3, 4
    #> $ found_from       <chr> "From initial search", "From initial search"
    #> $ concept_name     <chr> "Arthritis", "Osteoarthritis of knee"
    #> $ domain_id        <chr> "Condition", "Condition"
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard"

## Search using synonyms

We can also pick up codes based on their synonyms. In this case “Arthritis” has a synonym of “Osteoarthrosis” and so a search of both the primary name of a concept and any of its associated synonyms would pick up this synonym and it would be included.

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = "osteoarthrosis",
      domains = "Condition",
      searchInSynonyms = TRUE
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding concepts using synonymns
    #> condition domain: Adding descendants
    #> ✔ 4 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 4
    #> Columns: 6
    #> $ concept_id       <int> 2, 3, 4, 5
    #> $ found_from       <chr> "From initial search", "In synonyms", "From descendan…
    #> $ concept_name     <chr> "Osteoarthrosis", "Arthritis", "Osteoarthritis of kne…
    #> $ domain_id        <chr> "Condition", "Condition", "Condition", "Condition"
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED", "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard", "standard", "standard"

## Search via non-standard

Or we could have also picked up “Osteoarthrosis” by searching via non-standard.

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = c("arthritis", "arthropathy"),
      domains = "Condition",
      searchNonStandard = TRUE
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> condition domain: Adding codes from non-standard
    #> ✔ 4 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 4
    #> Columns: 6
    #> $ concept_id       <int> 3, 4, 5, 2
    #> $ found_from       <chr> "From initial search", "From initial search", "From i…
    #> $ concept_name     <chr> "Arthritis", "Osteoarthritis of knee", "Osteoarthriti…
    #> $ domain_id        <chr> "Condition", "Condition", "Condition", "Condition"
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED", "SNOMED", "SNOMED"
    #> $ standard_concept <chr> "standard", "standard", "standard", "standard"

## Search for both standard and non-standard concepts

We can also include non-standard codes in our results like so

    codes <- getCandidateCodes(
      cdm = cdm,
      keywords = c(
        "Musculoskeletal disorder",
        "arthritis",
        "arthropathy",
        "arthrosis"
      ),
      domains = "Condition",
      standardConcept = c("Standard", "Non-standard")
    )
    #> condition domain: Limiting to domains of interest
    #> condition: Getting concepts to include
    #> condition domain: Adding descendants
    #> ✔ 8 candidate concepts identified
    #>
    #> Time taken: 0 minutes and 0 seconds

    codes %>%
      glimpse()
    #> Rows: 8
    #> Columns: 6
    #> $ concept_id       <int> 1, 3, 4, 5, 8, 17, 7, 2
    #> $ found_from       <chr> "From initial search", "From initial search", "From i…
    #> $ concept_name     <chr> "Musculoskeletal disorder", "Arthritis", "Osteoarthri…
    #> $ domain_id        <chr> "Condition", "Condition", "Condition", "Condition", "…
    #> $ vocabulary_id    <chr> "SNOMED", "SNOMED", "SNOMED", "SNOMED", "Read", "ICD1…
    #> $ standard_concept <chr> "standard", "standard", "standard", "standard", "non-…